UniProt functional annotation for Q62645



	UniProt functional annotation for Q62645

UniProt code: Q62645.

Organism: Rattus norvegicus (Rat).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus.

Function: Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:7512349, PubMed:21522138, PubMed:23625947). Sensitivity to glutamate and channel kinetics depend on the subunit composition (PubMed:7512349, PubMed:23625947). {ECO:0000269|PubMed:21522138, ECO:0000269|PubMed:23625947, ECO:0000269|PubMed:7512349, ECO:0000305}.

Subunit: Heterotetramer. Forms heterotetrameric channels composed of two zeta subunits (GRIN1), and two epsilon subunits (GRIN2A, GRIN2B, GRIN2C or GRIN2D) (in vitro) (PubMed:21522138, PubMed:23625947). In vivo, the subunit composition may depend on the expression levels of the different subunits (Probable). Interacts with PDZ domains of PATJ and DLG4 (PubMed:7569905, PubMed:9647694). {ECO:0000269|PubMed:21522138, ECO:0000269|PubMed:23625947, ECO:0000269|PubMed:7569905, ECO:0000269|PubMed:9647694, ECO:0000305}.

Subcellular location: Cell membrane {ECO:0000269|PubMed:21522138, ECO:0000269|PubMed:23625947, ECO:0000269|PubMed:7512349}; Multi-pass membrane protein {ECO:0000305}. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.

Tissue specificity: Expressed in brain, mainly in the subcortical region.

Developmental stage: Already detected in embryonic stages, peaks at postnatal day 7, and decreases thereafter to adult levels.

Domain: A hydrophobic region that gives rise to the prediction of a transmembrane span does not cross the membrane, but is part of a discontinuously helical region that dips into the membrane and is probably part of the pore and of the selectivity filter. {ECO:0000250|UniProtKB:Q00960}.

Similarity: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR2D/GRIN2D subfamily. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.


Organism:		Rattus norvegicus (Rat).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus.



Function:		Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:7512349, PubMed:21522138, PubMed:23625947). Sensitivity to glutamate and channel kinetics depend on the subunit composition (PubMed:7512349, PubMed:23625947). {ECO:0000269\|PubMed:21522138, ECO:0000269\|PubMed:23625947, ECO:0000269\|PubMed:7512349, ECO:0000305}.


Subunit:		Heterotetramer. Forms heterotetrameric channels composed of two zeta subunits (GRIN1), and two epsilon subunits (GRIN2A, GRIN2B, GRIN2C or GRIN2D) (in vitro) (PubMed:21522138, PubMed:23625947). In vivo, the subunit composition may depend on the expression levels of the different subunits (Probable). Interacts with PDZ domains of PATJ and DLG4 (PubMed:7569905, PubMed:9647694). {ECO:0000269\|PubMed:21522138, ECO:0000269\|PubMed:23625947, ECO:0000269\|PubMed:7569905, ECO:0000269\|PubMed:9647694, ECO:0000305}.
Subcellular location:		Cell membrane {ECO:0000269\|PubMed:21522138, ECO:0000269\|PubMed:23625947, ECO:0000269\|PubMed:7512349}; Multi-pass membrane protein {ECO:0000305}. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.
Tissue specificity:		Expressed in brain, mainly in the subcortical region.
Developmental stage:		Already detected in embryonic stages, peaks at postnatal day 7, and decreases thereafter to adult levels.
Domain:		A hydrophobic region that gives rise to the prediction of a transmembrane span does not cross the membrane, but is part of a discontinuously helical region that dips into the membrane and is probably part of the pore and of the selectivity filter. {ECO:0000250\|UniProtKB:Q00960}.
Similarity:		Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR2D/GRIN2D subfamily. {ECO:0000305}.