PDBsum entry 3odo

Signaling protein

PDB id: 3odo

Contents

Protein chain

370 a.a.

PDB id:

3odo

Name:

Signaling protein

Title:

Crystal structure of the dh/ph domains of p115-rhogef

Structure:

Rho guanine nucleotide exchange factor 1. Chain: a, b. Fragment: dh-ph domain residues 395-766. Synonym: 115 kda guanine nucleotide exchange factor, p115-rhogef, p115rhogef, sub1.5. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: arhgef1. Expressed in: escherichia coli. Expression_system_taxid: 469008.

Resolution:

2.90Å R-factor: 0.223 R-free: 0.272

Authors:

Z.Chen,L.Guo,S.R.Sprang,P.C.Sternweis

Key ref:

Z.Chen et al. (2011). Modulation of a gef switch: autoinhibition of the int guanine nucleotide exchange activity of p115-Rhoref. Protein sci, 20, 107.

Date:

11-Aug-10 Release date: 05-Jan-11

Protein chains

Q92888  (ARHG1_HUMAN) -  Rho guanine nucleotide exchange factor 1 from Homo sapiens

Seq: 912 a.a.

Struc: 370 a.a.*

* PDB and UniProt seqs differ at 3 residue positions (black crosses)