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PDBsum entry 3ocs
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Transferase/transferase inhibitor
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PDB id
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3ocs
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Contents |
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* Residue conservation analysis
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PDB id:
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| Name: |
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Transferase/transferase inhibitor
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Title:
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Crystal structure of bruton's tyrosine kinase in complex with inhibitor cgi1746
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Structure:
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Tyrosine-protein kinase btk. Chain: a. Fragment: residues 393-656. Synonym: bruton tyrosine kinase, agammaglobulinaemia tyrosine kinase, atk, b-cell progenitor kinase, bpk. Engineered: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
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Resolution:
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1.80Å
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R-factor:
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0.184
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R-free:
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0.213
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Authors:
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D.R.Davies,S.L.Gallion,B.L.Staker
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Key ref:
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J.A.Di paolo
et al.
A novel, Specific btk inhibitor antagonizes bcr and fc[gamma]r signaling and suppresses inflammatory arth.
To be published,
.
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Date:
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10-Aug-10
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Release date:
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03-Nov-10
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PROCHECK
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Headers
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References
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Q06187
(BTK_HUMAN) -
Tyrosine-protein kinase BTK from Homo sapiens
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Seq:
Struc:
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659 a.a.
264 a.a.*
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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*
PDB and UniProt seqs differ
at 1 residue position (black
cross)
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Enzyme class:
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E.C.2.7.10.2
- non-specific protein-tyrosine kinase.
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Reaction:
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L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H+
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L-tyrosyl-[protein]
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+
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ATP
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=
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O-phospho-L-tyrosyl-[protein]
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+
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ADP
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+
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H(+)
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Links
