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PDBsum entry 3o8x
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Immune system
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PDB id
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3o8x
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Contents |
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268 a.a.
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96 a.a.
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203 a.a.
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239 a.a.
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* Residue conservation analysis
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PDB id:
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Immune system
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Title:
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Recognition of glycolipid antigen by inkt cell tcr
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Structure:
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Antigen-presenting glycoprotein cd1d1. Chain: a. Fragment: residues 19-297. Engineered: yes. Beta-2-microglobulin. Chain: b. Engineered: yes. Valpha14 chimera (mouse variable domain, human t-cell receptor alpha chain c region constant domain).
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Source:
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Mus musculus. Mouse. Organism_taxid: 10090. Gene: cd1d1, cd1.1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: b2m. Mus musculus, homo sapiens. Mouse, human.
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Resolution:
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2.74Å
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R-factor:
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0.198
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R-free:
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0.253
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Authors:
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D.M.Zajonc,Y.Li
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Key ref:
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Y.Li
et al.
(2010).
The Vα14 invariant natural killer T cell TCR forces microbial glycolipids and CD1d into a conserved binding mode.
J Exp Med,
207,
2383-2393.
PubMed id:
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Date:
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03-Aug-10
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Release date:
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29-Sep-10
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PROCHECK
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Headers
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References
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P11609
(CD1D1_MOUSE) -
Antigen-presenting glycoprotein CD1d1 from Mus musculus
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Seq:
Struc:
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336 a.a.
268 a.a.
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P01887
(B2MG_MOUSE) -
Beta-2-microglobulin from Mus musculus
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Seq:
Struc:
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119 a.a.
96 a.a.
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J Exp Med
207:2383-2393
(2010)
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PubMed id:
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The Vα14 invariant natural killer T cell TCR forces microbial glycolipids and CD1d into a conserved binding mode.
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Y.Li,
E.Girardi,
J.Wang,
E.D.Yu,
G.F.Painter,
M.Kronenberg,
D.M.Zajonc.
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ABSTRACT
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Literature references that cite this PDB file's key reference
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PubMed id
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Reference
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P.J.Brennan,
M.Brigl,
and
M.B.Brenner
(2013).
Invariant natural killer T cells: an innate activation scheme linked to diverse effector functions.
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Nat Rev Immunol,
13,
101-117.
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J.Rossjohn,
D.G.Pellicci,
O.Patel,
L.Gapin,
and
D.I.Godfrey
(2012).
Recognition of CD1d-restricted antigens by natural killer T cells.
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Nat Rev Immunol,
12,
845-857.
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K.S.Wun,
G.Cameron,
O.Patel,
S.S.Pang,
D.G.Pellicci,
L.C.Sullivan,
S.Keshipeddy,
M.H.Young,
A.P.Uldrich,
M.S.Thakur,
S.K.Richardson,
A.R.Howell,
P.A.Illarionov,
A.G.Brooks,
G.S.Besra,
J.McCluskey,
L.Gapin,
S.A.Porcelli,
D.I.Godfrey,
and
J.Rossjohn
(2011).
A molecular basis for the exquisite CD1d-restricted antigen specificity and functional responses of natural killer T cells.
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Immunity,
34,
327-339.
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PDB codes:
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S.Aspeslagh,
Y.Li,
E.D.Yu,
N.Pauwels,
M.Trappeniers,
E.Girardi,
T.Decruy,
K.Van Beneden,
K.Venken,
M.Drennan,
L.Leybaert,
J.Wang,
R.W.Franck,
S.Van Calenbergh,
D.M.Zajonc,
and
D.Elewaut
(2011).
Galactose-modified iNKT cell agonists stabilized by an induced fit of CD1d prevent tumour metastasis.
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EMBO J,
30,
2294-2305.
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PDB codes:
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T.Mallevaey,
A.J.Clarke,
J.P.Scott-Browne,
M.H.Young,
L.C.Roisman,
D.G.Pellicci,
O.Patel,
J.P.Vivian,
J.L.Matsuda,
J.McCluskey,
D.I.Godfrey,
P.Marrack,
J.Rossjohn,
and
L.Gapin
(2011).
A molecular basis for NKT cell recognition of CD1d-self-antigen.
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Immunity,
34,
315-326.
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PDB codes:
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W.Zhang,
C.Xia,
J.Nadas,
W.Chen,
L.Gu,
and
P.G.Wang
(2011).
Introduction of aromatic group on 4'-OH of α-GalCer manipulated NKT cell cytokine production.
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Bioorg Med Chem,
19,
2767-2776.
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The most recent references are shown first.
Citation data come partly from CiteXplore and partly
from an automated harvesting procedure. Note that this is likely to be
only a partial list as not all journals are covered by
either method. However, we are continually building up the citation data
so more and more references will be included with time.
Where a reference describes a PDB structure, the PDB
codes are
shown on the right.
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Links
