UniProt functional annotation for Q86YI8



	UniProt functional annotation for Q86YI8

UniProt code: Q86YI8.

Organism: Homo sapiens (Human).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.

Function: Modulates chromatin structure. Required for normal chromosome condensation during the early stages of mitosis. Required for normal chromosome separation during mitosis. {ECO:0000269|PubMed:19638409}.

Subunit: Interacts with histone H3 that is trimethylated at 'Lys-4' (H3K4me3). Interacts with GSK3B. {ECO:0000269|PubMed:19638409, ECO:0000269|Ref.8}.

Subcellular location: Nucleus {ECO:0000269|PubMed:19638409}. Nucleus, nucleoplasm {ECO:0000269|PubMed:19638409}. Note=Predominantly bound to chromatin, but a minor proportion is also detected in the nucleoplasm.

Induction: Expression levels are tightly regulated during the cell cycle. Strongly up-regulated during late G2 phase and M phase of the mitotic cell cycle. Down-regulated at the G1-S phase transition of the cell cycle. {ECO:0000269|PubMed:19638409}.

Ptm: Subject to proteasomal degradation. Stable when bound to chromatin. The soluble form is rapidly degraded.

Sequence caution: Sequence=AAH32792.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=BAD92781.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

Annotations taken from UniProtKB at the EBI.


Organism:		Homo sapiens (Human).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.



Function:		Modulates chromatin structure. Required for normal chromosome condensation during the early stages of mitosis. Required for normal chromosome separation during mitosis. {ECO:0000269\|PubMed:19638409}.


Subunit:		Interacts with histone H3 that is trimethylated at 'Lys-4' (H3K4me3). Interacts with GSK3B. {ECO:0000269\|PubMed:19638409, ECO:0000269\|Ref.8}.
Subcellular location:		Nucleus {ECO:0000269\|PubMed:19638409}. Nucleus, nucleoplasm {ECO:0000269\|PubMed:19638409}. Note=Predominantly bound to chromatin, but a minor proportion is also detected in the nucleoplasm.
Induction:		Expression levels are tightly regulated during the cell cycle. Strongly up-regulated during late G2 phase and M phase of the mitotic cell cycle. Down-regulated at the G1-S phase transition of the cell cycle. {ECO:0000269\|PubMed:19638409}.
Ptm:		Subject to proteasomal degradation. Stable when bound to chromatin. The soluble form is rapidly degraded.
Sequence caution:		Sequence=AAH32792.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=BAD92781.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};