UniProt functional annotation for Q13451

UniProt code: Q13451.

Organism: Homo sapiens (Human).
Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
 
Function: Immunophilin protein with PPIase and co-chaperone activities. Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors maintaining the complex into the cytoplasm when unliganded.
 
Catalytic activity: Peptidylproline (omega=180) = peptidylproline (omega=0).
Enzyme regulation: Inhibited by FK506 but not cyclosporin.
Subunit: Part of a heteromultimeric cytoplasmic complex with HSP90AA1, HSPA1A/HSPA1B and steroid receptors. Upon ligand binding dissociates from the complex and FKBP4 takes its place. Interacts with functionally mature heterooligomeric progesterone receptor complexes along with HSP90 and TEBP.
Subcellular location: Cytoplasm. Nucleus.
Tissue specificity: Widely expressed, enriched in testis compared to other tissues.
Induction: By androgen.
Similarity: Contains 2 PPIase FKBP-type domains.
Similarity: Contains 3 TPR repeats.
Sequence caution: Sequence=BAD93130.1; Type=Frameshift; Positions=29;

Annotations taken from UniProtKB at the EBI.