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UniProt functional annotation for P27930 | ||
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| UniProt code: P27930. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors. {ECO:0000269|PubMed:10975853, ECO:0000269|PubMed:12530978, ECO:0000269|PubMed:7989776, ECO:0000269|PubMed:9862719}. |
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| Subunit: | |
Associates with IL1RAP to form a non-signaling interleukin-1 receptor complex. {ECO:0000269|PubMed:20802483}. |
| Subcellular location: | |
[Isoform Short]: Secreted {ECO:0000269|PubMed:8702856}. |
| Subcellular location: | |
[Isoform Long]: Cell membrane; Single-pass type I membrane protein. |
| Ptm: | |
A soluble form (sIL1R2) can also be produced by proteolytic cleavage at the cell surface (shedding) involving a metalloproteinase; hovever, several sIL1R2 forms ranging from 45 and 60 kDa are reported. {ECO:0000269|PubMed:7989776, ECO:0000269|PubMed:9395521}. |
| Similarity: | |
Belongs to the interleukin-1 receptor family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.