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PDBsum entry 3o37
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Transcription/protein binding
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PDB id
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3o37
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References listed in PDB file
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Key reference
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Title
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Trim24 links a non-Canonical histone signature to breast cancer.
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Authors
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W.W.Tsai,
Z.Wang,
T.T.Yiu,
K.C.Akdemir,
W.Xia,
S.Winter,
C.Y.Tsai,
X.Shi,
D.Schwarzer,
W.Plunkett,
B.Aronow,
O.Gozani,
W.Fischle,
M.C.Hung,
D.J.Patel,
M.C.Barton.
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Ref.
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Nature, 2010,
468,
927-932.
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PubMed id
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Note: In the PDB file this reference is
annotated as "TO BE PUBLISHED". The citation details given above have
been manually determined.
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Abstract
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Recognition of modified histone species by distinct structural domains within
'reader' proteins plays a critical role in the regulation of gene expression.
Readers that simultaneously recognize histones with multiple marks allow
transduction of complex chromatin modification patterns into specific biological
outcomes. Here we report that chromatin regulator tripartite motif-containing 24
(TRIM24) functions in humans as a reader of dual histone marks by means of
tandem plant homeodomain (PHD) and bromodomain (Bromo) regions. The
three-dimensional structure of the PHD-Bromo region of TRIM24 revealed a single
functional unit for combinatorial recognition of unmodified H3K4 (that is,
histone H3 unmodified at lysine 4, H3K4me0) and acetylated H3K23 (histone H3
acetylated at lysine 23, H3K23ac) within the same histone tail. TRIM24 binds
chromatin and oestrogen receptor to activate oestrogen-dependent genes
associated with cellular proliferation and tumour development. Aberrant
expression of TRIM24 negatively correlates with survival of breast cancer
patients. The PHD-Bromo of TRIM24 provides a structural rationale for chromatin
activation through a non-canonical histone signature, establishing a new route
by which chromatin readers may influence cancer pathogenesis.
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