PDBsum entry 3o0j

Hydrolase/hydrolase inhibitor

PDB id: 3o0j

Contents

Protein chain

323 a.a.

Ligands

3OJ

EDO ×14

Metals

_ZN

_MG

Waters ×134

PDB id:

3o0j

Name:

Hydrolase/hydrolase inhibitor

Title:

Pde4b in complex with ligand an2898

Structure:

Camp-specific 3',5'-cyclic phosphodiesterase 4b. Chain: a. Synonym: dpde4, pde32. Engineered: yes

Source:

Homo sapiens. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008.

Resolution:

1.95Å R-factor: 0.187 R-free: 0.237

Authors:

M.R.K.Alley,Y.Zhou

Key ref:

Y.R.Freund et al. (2012). Boron-based phosphodiesterase inhibitors show novel binding of boron to PDE4 bimetal center. Febs Lett, 586, 3410-3414. PubMed id: 22841723

Date:

19-Jul-10 Release date: 10-Aug-11

Protein chain

Q07343  (PDE4B_HUMAN) -  3',5'-cyclic-AMP phosphodiesterase 4B from Homo sapiens

Seq: 736 a.a.

Struc: 323 a.a.

Enzyme reactions

• Enzyme class: E.C.3.1.4.53 - 3',5'-cyclic-AMP phosphodiesterase.
• Reaction: 3',5'-cyclic AMP + H2O = AMP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

Added reference

Febs Lett 586:3410-3414 (2012)

PubMed id: 22841723

Boron-based phosphodiesterase inhibitors show novel binding of boron to PDE4 bimetal center.

Y.R.Freund, T.Akama, M.R.Alley, J.Antunes, C.Dong, K.Jarnagin, R.Kimura, J.A.Nieman, K.R.Maples, J.J.Plattner, F.Rock, R.Sharma, R.Singh, V.Sanders, Y.Zhou.

ABSTRACT

No abstract given.