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PDBsum entry 3nzi
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Hydrolase/hydrolase substrate
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PDB id
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3nzi
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Contents |
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* Residue conservation analysis
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PDB id:
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| Name: |
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Hydrolase/hydrolase substrate
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Title:
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Substrate induced remodeling of the active site regulates htra1 activity
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Structure:
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Serine protease htra1. Chain: a. Fragment: unp residues 158-480. Synonym: l56, serine protease 11. Engineered: yes. Citrate synthase. Chain: b. Fragment: unp residues 371-377. Engineered: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: htra1, htra, prss11. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: peptidyl boronic acid inhibitor
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Resolution:
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2.75Å
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R-factor:
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0.202
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R-free:
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0.249
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Authors:
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L.Truebestein,A.Tennstaedt,P.Hauske,T.Krojer,M.Kaiser,T.Clausen, M.Ehrmann
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Key ref:
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L.Truebestein
et al.
(2011).
Substrate-induced remodeling of the active site regulates human HTRA1 activity.
Nat Struct Biol,
18,
386-388.
PubMed id:
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Date:
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16-Jul-10
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Release date:
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23-Feb-11
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PROCHECK
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Headers
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References
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Q92743
(HTRA1_HUMAN) -
Serine protease HTRA1 from Homo sapiens
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Seq:
Struc:
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480 a.a.
211 a.a.
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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Nat Struct Biol
18:386-388
(2011)
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PubMed id:
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Substrate-induced remodeling of the active site regulates human HTRA1 activity.
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L.Truebestein,
A.Tennstaedt,
T.Mönig,
T.Krojer,
F.Canellas,
M.Kaiser,
T.Clausen,
M.Ehrmann.
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ABSTRACT
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Literature references that cite this PDB file's key reference
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PubMed id
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Reference
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H.Malet,
F.Canellas,
J.Sawa,
J.Yan,
K.Thalassinos,
M.Ehrmann,
T.Clausen,
and
H.R.Saibil
(2012).
Newly folded substrates inside the molecular cage of the HtrA chaperone DegQ.
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Nat Struct Mol Biol,
19,
152-157.
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PDB codes:
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The most recent references are shown first.
Citation data come partly from CiteXplore and partly
from an automated harvesting procedure. Note that this is likely to be
only a partial list as not all journals are covered by
either method. However, we are continually building up the citation data
so more and more references will be included with time.
Where a reference describes a PDB structure, the PDB
codes are
shown on the right.
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Links
