PDBsum entry 3nz0

Transferase

PDB id

3nz0

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Contents

			Protein chain

					285 a.a. *

			Ligands

					IZA

			Waters ×173

* Residue conservation analysis

PDB id:

3nz0

Links

Name:

Transferase

Title:

Non-phosphorylated tyk2 kinase with cmp6

Structure:

Non-receptor tyrosine-protein kinase tyk2. Chain: a. Fragment: kinase domain jh1. Engineered: yes. Mutation: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: tyk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108

Resolution:

2.00Å

R-factor:

0.211

R-free:

0.253

Authors:

C.Eigenbrot,M.Ultsch

Key ref:

V.Tsui et al. (2011). A new regulatory switch in a JAK protein kinase. Proteins, 79, 393-401. PubMed id: 21117080

Date:

15-Jul-10

Release date:

20-Oct-10

PROCHECK

	Headers

	References

Protein chain

P29597 (TYK2_HUMAN) - Non-receptor tyrosine-protein kinase TYK2 from Homo sapiens

Seq: Struc:

Seq: Struc:

Seq: Struc:					1187 a.a. 285 a.a.*

Key:

PfamA domain

Secondary structure

CATH domain

* PDB and UniProt seqs differ at 3 residue positions (black crosses)



		Enzyme reactions

Enzyme class:

E.C.2.7.10.2 - non-specific protein-tyrosine kinase.

[IntEnz] [ExPASy] [KEGG] [BRENDA]

Reaction:

L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H⁺

L-tyrosyl-[protein]	+	ATP	=	O-phospho-L-tyrosyl-[protein]	+	ADP	+	H(+)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

Added reference

	Proteins 79:393-401 (2011)
PubMed id: 21117080

A new regulatory switch in a JAK protein kinase.
V.Tsui, P.Gibbons, M.Ultsch, K.Mortara, C.Chang, W.Blair, R.Pulk, M.Stanley, M.Starovasnik, D.Williams, M.Lamers, P.Leonard, S.Magnuson, J.Liang, C.Eigenbrot.

ABSTRACT

No abstract given.