|
|
||
|
|
|
|
|
UniProt functional annotation for P43250 | ||
|
|
|
|
|
|
||
| UniProt code: P43250. |
|
||
| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
|
||
|
||
| Function: | |
Specifically phosphorylates the activated forms of G protein- coupled receptors. Such receptor phosphorylation initiates beta- arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (By similarity). Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro). {ECO:0000250, ECO:0000269|PubMed:19801552, ECO:0000269|PubMed:20048153}. |
|
||
| Catalytic activity: | |
Reaction=[G-protein-coupled receptor] + ATP = [G-protein-coupled receptor]-phosphate + ADP + H(+); Xref=Rhea:RHEA:12008, Rhea:RHEA- COMP:11260, Rhea:RHEA-COMP:11261, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43176, ChEBI:CHEBI:68546, ChEBI:CHEBI:456216; EC=2.7.11.16; |
| Subunit: | |
Interacts with GIT1. {ECO:0000250|UniProtKB:P97711}. |
| Subcellular location: | |
Membrane; Lipid-anchor. |
| Tissue specificity: | |
Widely expressed. {ECO:0000269|PubMed:8415712}. |
| Ptm: | |
It is uncertain whether palmitoylation is on Cys-561 and/or Cys- 562 and/or Cys-565. {ECO:0000269|PubMed:7961702}. |
| Similarity: | |
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.