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PDBsum entry 3nxp

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protein ligands links
Hydrolase PDB id
3nxp
Jmol PyMol
Contents
Protein chain
388 a.a. *
Ligands
NAG
TRS ×2
GOL ×2
Waters ×197
* Residue conservation analysis
PDB id:
3nxp
Name: Hydrolase
Title: Crystal structure of human prethrombin-1
Structure: Prethrombin-1. Chain: a. Fragment: unp residues 199-622. Synonym: coagulation factor ii. Engineered: yes. Mutation: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f2. Expressed in: cricetulus griseus. Expression_system_taxid: 10029.
Resolution:
2.20Å     R-factor:   0.199     R-free:   0.226
Authors: Z.Chen,L.A.Bush-Pelc,E.Di Cera
Date:
14-Jul-10     Release date:   10-Nov-10    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
P00734  (THRB_HUMAN) -  Prothrombin
Seq:
Struc:
 
Seq:
Struc:
622 a.a.
388 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 1 residue position (black cross)

 Enzyme reactions 
   Enzyme class: E.C.3.4.21.5  - Thrombin.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: Preferential cleavage: Arg-|-Gly; activates fibrinogen to fibrin and releases fibrinopeptide A and B.
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     extracellular region   1 term 
  Biological process     blood coagulation   2 terms 
  Biochemical function     calcium ion binding     2 terms  

 

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