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PDBsum entry 3nvn
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protein ligands metals Protein-protein interface(s) links
Viral protein/signaling protein PDB id
3nvn

 

 

 

 

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Contents
Protein chains
383 a.a. *
474 a.a. *
Ligands
NDG ×3
NAG ×5
Metals
_CA
Waters ×509
* Residue conservation analysis
PDB id:
3nvn
Name: Viral protein/signaling protein
Title: Molecular mechanism of guidance cue recognition
Structure: Evm139. Chain: a. Fragment: unp residues 15-399. Synonym: semaphorin. Engineered: yes. Plexin-c1. Chain: b. Fragment: unp residues 35-507. Synonym: virus-encoded semaphorin protein receptor.
Source: Ectromelia virus. Organism_taxid: 12643. Gene: sema. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell: hek293s. Homo sapiens. Human. Organism_taxid: 9606.
Resolution:
2.26Å     R-factor:   0.239     R-free:   0.276
Authors: H.Liu,Z.Juo,A.Shim,P.Focia,X.Chen,C.Garcia,X.He
Key ref: H.Liu et al. (2010). Structural basis of semaphorin-plexin recognition and viral mimicry from Sema7A and A39R complexes with PlexinC1. Cell, 142, 749-761. PubMed id: 20727575
Date:
08-Jul-10     Release date:   15-Sep-10    
PROCHECK
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 Headers
 References

Protein chain
Pfam   ArchSchema ?
Q8JL80  (SEMA_ECTVM) -  Semaphorin-like protein 139 from Ectromelia virus (strain Moscow)
Seq:
Struc: 		399 a.a.
383 a.a.*
Protein chain
Pfam   ArchSchema ?
O60486  (PLXC1_HUMAN) -  Plexin-C1 from Homo sapiens
Seq:
Struc: 		 
Seq:
Struc: 		 
Seq:
Struc: 		 
Seq:
Struc: 		1568 a.a.
474 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 4 residue positions (black crosses)

 

 
Cell 142:749-761 (2010)
PubMed id: 20727575  
 
 
Structural basis of semaphorin-plexin recognition and viral mimicry from Sema7A and A39R complexes with PlexinC1.
H.Liu, Z.S.Juo, A.H.Shim, P.J.Focia, X.Chen, K.C.Garcia, X.He.
 
  ABSTRACT  
 
No abstract given.

 

Literature references that cite this PDB file's key reference

  PubMed id Reference
23104057 B.J.Janssen, T.Malinauskas, G.A.Weir, M.Z.Cader, C.Siebold, and E.Y.Jones (2012).
Neuropilins lock secreted semaphorins onto plexins in a ternary signaling complex.
  Nat Struct Mol Biol, 19, 1293-1299.
PDB codes: 4gz8 4gz9 4gza
22902366 J.Elegheert, N.Bracke, P.Pouliot, I.Gutsche, A.V.Shkumatov, N.Tarbouriech, K.Verstraete, A.Bekaert, W.P.Burmeister, D.I.Svergun, B.N.Lambrecht, B.Vergauwen, and S.N.Savvides (2012).
Allosteric competitive inactivation of hematopoietic CSF-1 signaling by the viral decoy receptor BARF1.
  Nat Struct Mol Biol, 19, 938-947.
PDB codes: 3uez 3uf2 3uf5 4adf 4adq
20877282 B.J.Janssen, R.A.Robinson, F.Pérez-Brangulí, C.H.Bell, K.J.Mitchell, C.Siebold, and E.Y.Jones (2010).
Structural basis of semaphorin-plexin signalling.
  Nature, 467, 1118-1122.
PDB codes: 3okt 3okw 3oky 3ol2
20881961 T.Nogi, N.Yasui, E.Mihara, Y.Matsunaga, M.Noda, N.Yamashita, T.Toyofuku, S.Uchiyama, Y.Goshima, A.Kumanogoh, and J.Takagi (2010).
Structural basis for semaphorin signalling through the plexin receptor.
  Nature, 467, 1123-1127.
PDB codes: 3afc 3al8 3al9
The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time. Where a reference describes a PDB structure, the PDB codes are shown on the right.

 

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