PDBsum entry 3ntp

Isomerase/isomerase inhibitor

PDB id: 3ntp

Contents

Protein chain

147 a.a.

Ligands

RZD

PE8

Waters ×86

PDB id:

3ntp

Name:

Isomerase/isomerase inhibitor

Title:

Human pin1 complexed with reduced amide inhibitor

Structure:

Peptidyl-prolyl cis-trans isomerase nima-interacting 1. Chain: a. Synonym: peptidyl-prolyl cis-trans isomerase pin1, ppiase pin1, rotamase pin1. Engineered: yes. Mutation: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: pin1. Expressed in: escherichia coli. Expression_system_taxid: 562.

Resolution:

1.76Å R-factor: 0.233 R-free: 0.266

Authors:

Y.Zhang

Key ref:

G.G.Xu et al. (2011). A reduced-amide inhibitor of Pin1 binds in a conformation resembling a twisted-amide transition state. Biochemistry, 50, 9545-9550. PubMed id: 21980916

Date:

05-Jul-10 Release date: 04-Jan-12

Protein chain

Q13526  (PIN1_HUMAN) -  Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 from Homo sapiens

Seq: 163 a.a.

Struc: 147 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class: E.C.5.2.1.8 - peptidylprolyl isomerase.
• Reaction: [protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

Added reference

Biochemistry 50:9545-9550 (2011)

PubMed id: 21980916

A reduced-amide inhibitor of Pin1 binds in a conformation resembling a twisted-amide transition state.

G.G.Xu, Y.Zhang, A.Y.Mercedes-Camacho, F.A.Etzkorn.

ABSTRACT

No abstract given.