PDBsum entry 3nss

Hydrolase

PDB id: 3nss

Contents

Protein chains

387 a.a.

Ligands

NAG-NAG-MAN-MAN

NAG ×3

ACT ×4

Metals

_CA ×5

Waters ×889

References listed in PDB file

Key reference

• Title: The 2009 pandemic h1n1 neuraminidase n1 lacks the 150-Cavity in its active site.
• Authors: Q.Li, J.Qi, W.Zhang, C.J.Vavricka, Y.Shi, J.Wei, E.Feng, J.Shen, J.Chen, D.Liu, J.He, J.Yan, H.Liu, H.Jiang, M.Teng, X.Li, G.F.Gao.
• Ref.: Nat Struct Biol, 2010, 17, 1266-1268.
• PubMed id: 20852645

Abstract

Influenza A virus neuraminidase can be classified into groups 1 and 2 on the basis of its primary structure. The main structural feature of group 1 neuraminidase is an extra cavity in the active site, the 150-cavity. Here we present the crystal structure of neuraminidase from the 2009 pandemic H1N1 influenza strain. In contrast to other characterized N1 neuraminidases, which are all members of group 1, 2009 H1N1 neuraminidase does not have a 150-cavity.