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UniProt functional annotation for Q9VAM9 | ||
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| UniProt code: Q9VAM9. |
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| Organism: | |
Drosophila melanogaster (Fruit fly). |
| Taxonomy: | |
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora. |
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| Function: | |
ppGpp hydrolyzing enzyme involved in starvation response. {ECO:0000269|PubMed:20818390}. |
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| Catalytic activity: | |
Reaction=guanosine 3',5'-bis(diphosphate) + H2O = diphosphate + GDP + H(+); Xref=Rhea:RHEA:14253, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:58189, ChEBI:CHEBI:77828; EC=3.1.7.2; Evidence={ECO:0000269|PubMed:20818390}; |
| Cofactor: | |
Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000269|PubMed:20818390}; |
| Disruption phenotype: | |
Induces retarded body growth and impaired starvation resistance. Mutants have highly down-regulated DNA and protein synthesis-related genes and up-regulated stress-responsible genes. {ECO:0000269|PubMed:20818390}. |
| Similarity: | |
Belongs to the MESH1 family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.