PDBsum entry 3npz

Hormone/hormone receptor

PDB id: 3npz

Contents

Protein chains

186 a.a. *

202 a.a. *

* Residue conservation analysis

PDB id:

3npz

Name:

Hormone/hormone receptor

Title:

Prolactin receptor (prlr) complexed with the natural hormone (prl)

Structure:

Prolactin. Chain: a. Synonym: prl. Engineered: yes. Prolactin receptor. Chain: b, c. Fragment: prlr (unp residues 20-229). Synonym: prl-r, lactogen receptor. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: hcg_36753, prl, rp3-404k8.1-001. Expressed in: escherichia coli. Expression_system_taxid: 469008. Rattus norvegicus. Brown rat,rat,rats. Organism_taxid: 10116.

Resolution:

3.35Å R-factor: 0.237 R-free: 0.293

Authors:

J.Van Agthoven,P.England,V.Goffin,I.Broutin

Key ref:

J.van Agthoven et al. (2010). Structural characterization of the stem-stem dimerization interface between prolactin receptor chains complexed with the natural hormone. J Mol Biol, 404, 112-126. PubMed id: 20875426

Date:

29-Jun-10 Release date: 06-Oct-10

Protein chain

P01236  (PRL_HUMAN) -  Prolactin from Homo sapiens

Seq: 227 a.a.

Struc: 186 a.a.

Protein chains

P05710  (PRLR_RAT) -  Prolactin receptor from Rattus norvegicus

Seq: 610 a.a.

Struc: 202 a.a.

J Mol Biol 404:112-126 (2010)

PubMed id: 20875426

Structural characterization of the stem-stem dimerization interface between prolactin receptor chains complexed with the natural hormone.

J.van Agthoven, C.Zhang, E.Tallet, B.Raynal, S.Hoos, B.Baron, P.England, V.Goffin, I.Broutin.

ABSTRACT

No abstract given.