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PDBsum entry 3njy

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protein ligands metals Protein-protein interface(s) links
Oxidoreductase/oxidoreductase inhibitor PDB id
3njy
Jmol PyMol
Contents
Protein chains
347 a.a. *
Ligands
8XQ ×2
Metals
_NI ×2
_ZN ×2
Waters ×284
* Residue conservation analysis
PDB id:
3njy
Name: Oxidoreductase/oxidoreductase inhibitor
Title: Crystal structure of jmjd2a complexed with 5-carboxy-8- hydroxyquinoline
Structure: Lysine-specific demethylase 4a. Chain: a, b. Fragment: catalytic domain. Synonym: jmjc domain-containing histone demethylation prote jumonji domain-containing protein 2a. Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Resolution:
2.60Å     R-factor:   0.182     R-free:   0.226
Authors: O.N.F.King,I.J.Clifton,M.Wang,D.J.Maloney,A.Jadhav,U.Opperma T.D.Heightman,A.Simeonov,M.A.Mcdonough,C.J.Schofield
Key ref: O.N.King et al. (2010). Quantitative high-throughput screening identifies 8-hydroxyquinolines as cell-active histone demethylase inhibitors. PLoS One, 5, e15535. PubMed id: 21124847
Date:
18-Jun-10     Release date:   08-Dec-10    
PROCHECK
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 Headers
 References

Protein chains
Pfam   ArchSchema ?
O75164  (KDM4A_HUMAN) -  Lysine-specific demethylase 4A
Seq:
Struc:
 
Seq:
Struc:
 
Seq:
Struc:
1064 a.a.
347 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.1.14.11.-  - ?????
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]

 

 
PLoS One 5:e15535 (2010)
PubMed id: 21124847  
 
 
Quantitative high-throughput screening identifies 8-hydroxyquinolines as cell-active histone demethylase inhibitors.
O.N.King, X.S.Li, M.Sakurai, A.Kawamura, N.R.Rose, S.S.Ng, A.M.Quinn, G.Rai, B.T.Mott, P.Beswick, R.J.Klose, U.Oppermann, A.Jadhav, T.D.Heightman, D.J.Maloney, C.J.Schofield, A.Simeonov.
 
  ABSTRACT  
 
No abstract given.

 

Literature references that cite this PDB file's key reference

  PubMed id Reference
22498752 C.H.Arrowsmith, C.Bountra, P.V.Fish, K.Lee, and M.Schapira (2012).
Epigenetic protein families: a new frontier for drug discovery.
  Nat Rev Drug Discov, 11, 384-400.  
  21412984 K.H.Chang, O.N.King, A.Tumber, E.C.Woon, T.D.Heightman, M.A.McDonough, C.J.Schofield, and N.R.Rose (2011).
Inhibition of histone demethylases by 4-carboxy-2,2'-bipyridyl compounds.
  ChemMedChem, 6, 759-764.
PDB code: 3pdq
21460794 R.Chowdhury, K.K.Yeoh, Y.M.Tian, L.Hillringhaus, E.A.Bagg, N.R.Rose, I.K.Leung, X.S.Li, E.C.Woon, M.Yang, M.A.McDonough, O.N.King, I.J.Clifton, R.J.Klose, T.D.Claridge, P.J.Ratcliffe, C.J.Schofield, and A.Kawamura (2011).
The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases.
  EMBO Rep, 12, 463-469.
PDB codes: 2ybk 2ybp 2ybs 2yc0 2yde
The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time. Where a reference describes a PDB structure, the PDB code is shown on the right.

 

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