PDBsum entry 3nha

Transport protein

PDB id: 3nha

Contents

Protein chain

278 a.a. *

Ligands

PO4

ADP

BME ×2

Metals

_MG

Waters ×129

* Residue conservation analysis

PDB id:

3nha

Name:

Transport protein

Title:

Nucleotide binding domain of human abcb6 (adp mg bound structure)

Structure:

Atp-binding cassette sub-family b member 6, mitochondrial. Chain: a. Fragment: nucleotide binding domain of the human acb-transporter abcb6. Synonym: mitochondrial abc transporter 3, mt-abc transporter 3, ubiquitously-expressed mammalian abc half transporter, p- glycoprotein-related protein. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: abcb6, mtabc3, prp, umat. Expressed in: escherichia coli. Expression_system_taxid: 562.

Resolution:

2.10Å R-factor: 0.187 R-free: 0.252

Authors:

M.Haffke,A.Menzel,Y.Carius,D.Jahn,D.W.Heinz

Key ref:

M.Haffke et al. (2010). Structures of the nucleotide-binding domain of the human ABCB6 transporter and its complexes with nucleotides. Acta Crystallogr D Biol Crystallogr, 66, 979-987. PubMed id: 20823549

Date:

14-Jun-10 Release date: 25-Aug-10

Protein chain

Q9NP58  (ABCB6_HUMAN) -  ATP-binding cassette sub-family B member 6 from Homo sapiens

Seq: 842 a.a.

Struc: 278 a.a.*

* PDB and UniProt seqs differ at 8 residue positions (black crosses)

Enzyme reactions

• Enzyme class: E.C.7.6.2.5 - ABC-type heme transporter.
• Reaction: heme b(in) + ATP + H2O = heme b(out) + ADP + phosphate + H⁺

heme b(in) + ATP + H2O = heme b(out) (Bound ligand (Het Group name = ADP) corresponds exactly) + ADP + phosphate + H(+) (Bound ligand (Het Group name = PO4) corresponds exactly)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

reference

Acta Crystallogr D Biol Crystallogr 66:979-987 (2010)

PubMed id: 20823549

Structures of the nucleotide-binding domain of the human ABCB6 transporter and its complexes with nucleotides.

M.Haffke, A.Menzel, Y.Carius, D.Jahn, D.W.Heinz.

ABSTRACT

No abstract given.