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PDBsum entry 3ng2
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protein ligands metals Protein-protein interface(s) links
Metal binding protein PDB id
3ng2

 

 

 

 

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Contents
Protein chains
66 a.a. *
Ligands
SO4
Metals
_ZN ×4
Waters ×43
* Residue conservation analysis
PDB id:
3ng2
Name: Metal binding protein
Title: Crystal structure of the rnf4 ring domain dimer
Structure: Ring finger protein 4. Chain: a, b. Fragment: ring domain. Synonym: rnf4, snurf. Engineered: yes
Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: rnf4. Expressed in: escherichia coli. Expression_system_taxid: 562.
Resolution:
1.80Å     R-factor:   0.190     R-free:   0.242
Authors: C.W.Liew,C.L.Day
Key ref: C.W.Liew et al. (2010). RING domain dimerization is essential for RNF4 function. Biochem J, 431, 23-29. PubMed id: 20681948
Date:
10-Jun-10     Release date:   06-Oct-10    
PROCHECK
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 Headers
 References

Protein chains
Pfam   ArchSchema ?
O88846  (RNF4_RAT) -  E3 ubiquitin-protein ligase RNF4 from Rattus norvegicus
Seq:
Struc: 		194 a.a.
66 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.2.3.2.27  - RING-type E3 ubiquitin transferase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6- ubiquitinyl-[acceptor protein]-L-lysine

 

 
Biochem J 431:23-29 (2010)
PubMed id: 20681948  
 
 
RING domain dimerization is essential for RNF4 function.
C.W.Liew, H.Sun, T.Hunter, C.L.Day.
 
  ABSTRACT  
 
No abstract given.

 

Literature references that cite this PDB file's key reference

  PubMed id Reference
22842904 A.Plechanovová, E.G.Jaffray, M.H.Tatham, J.H.Naismith, and R.T.Hay (2012).
Structure of a RING E3 ligase and ubiquitin-loaded E2 primed for catalysis.
  Nature, 489, 115-120.
PDB code: 4ap4
21857666 A.Plechanovová, E.G.Jaffray, S.A.McMahon, K.A.Johnson, I.Navrátilová, J.H.Naismith, and R.T.Hay (2011).
Mechanism of ubiquitylation by dimeric RING ligase RNF4.
  Nat Struct Mol Biol, 18, 1052-1059.
PDB code: 2xeu
The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time. Where a reference describes a PDB structure, the PDB code is shown on the right.

 

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