PDBsum entry 3nfp

Immune system/cytokine

PDB id: 3nfp

Contents

Protein chains

213 a.a. *

212 a.a. *

124 a.a. *

111 a.a. *

Waters ×97

* Residue conservation analysis

PDB id:

3nfp

Name:

Immune system/cytokine

Title:

Crystal structure of the fab fragment of therapeutic antibody daclizumab in complex with il-2ra (cd25) ectodomain

Structure:

Heavy chain of fab fragment of daclizumab. Chain: a, h. Engineered: yes. Light chain of fab fragment of daclizumab. Chain: b, l. Engineered: yes. Interleukin-2 receptor subunit alpha. Chain: i, k. Fragment: unp residues 22-238.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Other_details: purchased from roche, expressed in a mammalian expression system. Gene: il2ra. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: hi-5.

Resolution:

2.86Å R-factor: 0.255 R-free: 0.301

Authors:

H.Yang,J.Wang,J.Du,C.Zhong,Y.Guo,J.Ding

Key ref:

H.Yang et al. (2010). Structural basis of immunosuppression by the therapeutic antibody daclizumab. Cell Res, 20, 1361-1371. PubMed id: 20820193

Date:

10-Jun-10 Release date: 15-Sep-10

Protein chains

No UniProt id for this chain

Struc: 213 a.a.

Protein chains

No UniProt id for this chain

Struc: 212 a.a.

Protein chain

P01589  (IL2RA_HUMAN) -  Interleukin-2 receptor subunit alpha from Homo sapiens

Seq: 272 a.a.

Struc: 124 a.a.

Protein chain

P01589  (IL2RA_HUMAN) -  Interleukin-2 receptor subunit alpha from Homo sapiens

Seq: 272 a.a.

Struc: 111 a.a.

Cell Res 20:1361-1371 (2010)

PubMed id: 20820193

Structural basis of immunosuppression by the therapeutic antibody daclizumab.

H.Yang, J.Wang, J.Du, C.Zhong, D.Zhang, H.Guo, Y.Guo, J.Ding.

ABSTRACT

No abstract given.