PDBsum entry 3nfk

Protein binding

PDB id: 3nfk

Contents

Protein chains

92 a.a.

13 a.a.

Ligands

GLY-GLU-THR-ARG-LEU

GOL ×2

Waters ×185

PDB id:

3nfk

Name:

Protein binding

Title:

Crystal structure of the ptpn4 pdz domain complexed with thE C- terminus of a rabies virus g protein

Structure:

Tyrosine-protein phosphatase non-receptor type 4. Chain: a, b. Fragment: pdz domain (unp residues 499-604). Synonym: protein-tyrosine phosphatase meg1, ptpase-meg1, meg. Engineered: yes. Glycoprotein g. Chain: c, d. Fragment: unp residues 512-524. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: ptpn4. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes. Rabies virus. Organism_taxid: 11292.

Resolution:

1.43Å R-factor: 0.193 R-free: 0.204

Authors:

N.Babault,F.Cordier,M.Lafage,J.Cockburn,A.Haouz,F.A.Rey,M.Delepierre, H.Buc,M.Lafon,N.Wolff

Key ref:

N.Babault et al. (2011). Peptides targeting the PDZ domain of PTPN4 are efficient inducers of glioblastoma cell death. Structure, 19, 1518-1524. PubMed id: 22000519

Date:

10-Jun-10 Release date: 24-Aug-11

Protein chains

P29074  (PTN4_HUMAN) -  Tyrosine-protein phosphatase non-receptor type 4 from Homo sapiens

Seq: 926 a.a.

Struc: 92 a.a.

Protein chain

P03524  (GLYCO_RABVE) -  Glycoprotein from Rabies virus (strain ERA)

Seq: 524 a.a.

Struc: 13 a.a.

Enzyme reactions

• Enzyme class: Chains A, B: E.C.3.1.3.48 - protein-tyrosine-phosphatase.
• Reaction: O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

Key reference

Structure 19:1518-1524 (2011)

PubMed id: 22000519

Peptides targeting the PDZ domain of PTPN4 are efficient inducers of glioblastoma cell death.

N.Babault, F.Cordier, M.Lafage, J.Cockburn, A.Haouz, C.Prehaud, F.A.Rey, M.Delepierre, H.Buc, M.Lafon, N.Wolff.

ABSTRACT

No abstract given.