PDBsum entry 3nc1

Gtp-binding protein/transport protein

PDB id

3nc1

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Contents

			Protein chains

					173 a.a. *


					1026 a.a. *

			Ligands

					GTP

			Metals

					_MG

* Residue conservation analysis

PDB id:

3nc1

Links

Name:

Gtp-binding protein/transport protein

Title:

Crystal structure of the crm1-rangtp complex

Structure:

Gtp-binding nuclear protein ran. Chain: c. Synonym: gtpase ran, ras-related nuclear protein, ras-like protein tc4, androgen receptor-associated protein 24. Engineered: yes. Mutation: yes. Exportin-1. Chain: a. Synonym: exp1, chromosome region maintenance 1 protein homolog.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: ara24, ok/sw-cl.81, ran, ran (geneid: 5901). Expressed in: escherichia coli. Expression_system_taxid: 562. Mus musculus. Mouse. Organism_taxid: 10090.

Resolution:

3.35Å

R-factor:

0.221

R-free:

0.254

Authors:

T.Guttler,T.Madl,P.Neumann,D.Deichsel,L.Corsini,T.Monecke,R.Ficner, M.Sattler,D.Gorlich

Key ref:

T.Güttler et al. (2010). NES consensus redefined by structures of PKI-type and Rev-type nuclear export signals bound to CRM1. Nat Struct Biol, 17, 1367-1376. PubMed id: 20972448

Date:

04-Jun-10

Release date:

27-Oct-10

PROCHECK

	Headers

	References

Protein chain

P62826 (RAN_HUMAN) - GTP-binding nuclear protein Ran from Homo sapiens

Seq: Struc:					216 a.a. 173 a.a.*

Protein chain

Q6P5F9 (XPO1_MOUSE) - Exportin-1 from Mus musculus

Seq: Struc:

Seq: Struc:

Seq: Struc:					1071 a.a. 1026 a.a.

Key:

PfamA domain

Secondary structure

CATH domain

* PDB and UniProt seqs differ at 1 residue position (black cross)



		Enzyme reactions

Enzyme class 2:

Chain A: E.C.?

[IntEnz] [ExPASy] [KEGG] [BRENDA]

Enzyme class 3:

Chain C: E.C.3.6.5.- - ?????

[IntEnz] [ExPASy] [KEGG] [BRENDA]

Note, where more than one E.C. class is given (as above), each may correspond to a different protein domain or, in the case of polyprotein precursors, to a different mature protein.

	Nat Struct Biol 17:1367-1376 (2010)
PubMed id: 20972448

NES consensus redefined by structures of PKI-type and Rev-type nuclear export signals bound to CRM1.
T.Güttler, T.Madl, P.Neumann, D.Deichsel, L.Corsini, T.Monecke, R.Ficner, M.Sattler, D.Görlich.

ABSTRACT

No abstract given.

Literature references that cite this PDB file's key reference

PubMed id

Reference

21364925

K.Langer, C.Dian, V.Rybin, C.W.Müller, and C.Petosa (2011).
Insights into the Function of the CRM1 Cofactor RanBP3 from the Structure of Its Ran-Binding Domain.

PLoS One, 6, e17011.

PDB codes:

2y8f 2y8g

21088665

I.W.Mattaj, and C.W.Müller (2010).
Solving the NES problem.

Nat Struct Mol Biol, 17, 1288-1289.

The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time. Where a reference describes a PDB structure, the PDB codes are shown on the right.