UniProt functional annotation for Q92585



	UniProt functional annotation for Q92585

UniProt code: Q92585.

Organism: Homo sapiens (Human).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.

Function: Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions. {ECO:0000269|PubMed:11101851, ECO:0000269|PubMed:11390662, ECO:0000269|PubMed:12050117, ECO:0000269|PubMed:15546612, ECO:0000269|PubMed:17317671}.

Subunit: Interacts (via N-terminus) with NOTCH1, NOTCH2, NOTCH3 and NOTCH4 (via ankyrin repeat region). Interacts (via N-terminus) with p53 (via DNA-binding region). Forms a DNA-binding complex with Notch proteins and RBPSUH/RBP-J kappa/CBF1. Also binds CREBBP/CBP and CDK8.Forms a complex with PRAG1, NOTCH1 and MAML1, in a MAML1-dependent manner (By similarity). {ECO:0000250|UniProtKB:Q6T264, ECO:0000269|PubMed:11101851, ECO:0000269|PubMed:11390662, ECO:0000269|PubMed:12050117, ECO:0000269|PubMed:15546612, ECO:0000269|PubMed:16530044, ECO:0000269|PubMed:17317671}.

Subcellular location: Nucleus speckle {ECO:0000269|PubMed:11101851}. Note=Nuclear, in a punctate manner.

Tissue specificity: Widely expressed with highest levels in heart, pancreas, peripheral blood leukocytes and spleen. {ECO:0000269|PubMed:11101851}.

Domain: The C-terminal region is required for transcriptional activation. {ECO:0000269|PubMed:11101851}.

Similarity: Belongs to the mastermind family. {ECO:0000305}.

Sequence caution: Sequence=BAA12114.2; Type=Erroneous initiation; Evidence={ECO:0000305};

Annotations taken from UniProtKB at the EBI.


Organism:		Homo sapiens (Human).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.



Function:		Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions. {ECO:0000269\|PubMed:11101851, ECO:0000269\|PubMed:11390662, ECO:0000269\|PubMed:12050117, ECO:0000269\|PubMed:15546612, ECO:0000269\|PubMed:17317671}.


Subunit:		Interacts (via N-terminus) with NOTCH1, NOTCH2, NOTCH3 and NOTCH4 (via ankyrin repeat region). Interacts (via N-terminus) with p53 (via DNA-binding region). Forms a DNA-binding complex with Notch proteins and RBPSUH/RBP-J kappa/CBF1. Also binds CREBBP/CBP and CDK8.Forms a complex with PRAG1, NOTCH1 and MAML1, in a MAML1-dependent manner (By similarity). {ECO:0000250\|UniProtKB:Q6T264, ECO:0000269\|PubMed:11101851, ECO:0000269\|PubMed:11390662, ECO:0000269\|PubMed:12050117, ECO:0000269\|PubMed:15546612, ECO:0000269\|PubMed:16530044, ECO:0000269\|PubMed:17317671}.
Subcellular location:		Nucleus speckle {ECO:0000269\|PubMed:11101851}. Note=Nuclear, in a punctate manner.
Tissue specificity:		Widely expressed with highest levels in heart, pancreas, peripheral blood leukocytes and spleen. {ECO:0000269\|PubMed:11101851}.
Domain:		The C-terminal region is required for transcriptional activation. {ECO:0000269\|PubMed:11101851}.
Similarity:		Belongs to the mastermind family. {ECO:0000305}.
Sequence caution:		Sequence=BAA12114.2; Type=Erroneous initiation; Evidence={ECO:0000305};