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PDBsum entry 3naz

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protein ligands Protein-protein interface(s) links
Transferase PDB id
3naz
Jmol PyMol
Contents
Protein chains
611 a.a. *
Ligands
UNK-UNK-UNK-UNK-
UNK
UNK-UNK-UNK-UNK-
UNK-UNK
SO4 ×16
* Residue conservation analysis
PDB id:
3naz
Name: Transferase
Title: Basal state form of yeast glycogen synthase
Structure: Glycogen [starch] synthase isoform 2. Chain: a, b, c, d. Engineered: yes. Mutation: yes. Peptide. Chain: e, f. Engineered: yes
Source: Saccharomyces cerevisiae. Brewer's yeast,lager beer yeast,yeast. Organism_taxid: 4932. Gene: gsy2, l8479.8, ylr258w. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Resolution:
3.00Å     R-factor:   0.205     R-free:   0.254
Authors: S.Baskaran,T.D.Hurley
Key ref: S.Baskaran et al. (2010). Structural basis for glucose-6-phosphate activation of glycogen synthase. Proc Natl Acad Sci U S A, 107, 17563-17568. PubMed id: 20876143
Date:
02-Jun-10     Release date:   06-Oct-10    
PROCHECK
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 Headers
 References

Protein chains
Pfam   ArchSchema ?
P27472  (GYS2_YEAST) -  Glycogen [starch] synthase isoform 2
Seq:
Struc:
 
Seq:
Struc:
705 a.a.
611 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 4 residue positions (black crosses)

 Enzyme reactions 
   Enzyme class: E.C.2.4.1.11  - Glycogen(starch) synthase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]

      Pathway:
Glycogen
      Reaction: UDP-alpha-D-glucose + ((1->4)-alpha-D-glucosyl)(n) = UDP + ((1->4)-alpha- D-glucosyl)(n+1)
UDP-alpha-D-glucose
+ ((1->4)-alpha-D-glucosyl)(n)
= UDP
+ ((1->4)-alpha- D-glucosyl)(n+1)
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     cytoplasm   1 term 
  Biological process     metabolic process   2 terms 
  Biochemical function     catalytic activity     4 terms  

 

 
    Added reference    
 
 
Proc Natl Acad Sci U S A 107:17563-17568 (2010)
PubMed id: 20876143  
 
 
Structural basis for glucose-6-phosphate activation of glycogen synthase.
S.Baskaran, P.J.Roach, A.A.DePaoli-Roach, T.D.Hurley.
 
  ABSTRACT  
 
No abstract given.

 

Literature references that cite this PDB file's key reference

  PubMed id Reference
21356517 V.S.Tagliabracci, C.Heiss, C.Karthik, C.J.Contreras, J.Glushka, M.Ishihara, P.Azadi, T.D.Hurley, A.A.DePaoli-Roach, and P.J.Roach (2011).
Phosphate incorporation during glycogen synthesis and Lafora disease.
  Cell Metab, 13, 274-282.  
The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time.

 

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