UniProt functional annotation for Q9Y6X8



	UniProt functional annotation for Q9Y6X8

UniProt code: Q9Y6X8.

Organism: Homo sapiens (Human).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.

Function: Acts as a transcriptional repressor (PubMed:12741956). Represses the promoter activity of the CDC25C gene stimulated by NFYA (PubMed:12741956). May play a role in retinal development where it regulates the composition of bipolar cell populations, by promoting differentiation of bipolar OFF-type cells (By similarity). In the brain, may promote maintenance and suppress differentiation of neural progenitor cells in the developing cortex (By similarity). {ECO:0000250|UniProtKB:Q8C0C0, ECO:0000269|PubMed:12741956}.

Subunit: Homodimer (via homeobox domain) (PubMed:12741956, PubMed:14659886). Heterodimer with ZHX1 (via homeobox domain 1) (PubMed:12741956). Heterodimer with ZHX3 (via homeobox domain 1) (PubMed:12741956, PubMed:14659886). Heterodimerization with ZHX1 is not necessary for repressor activity (PubMed:12741956). Interacts (via homeobox domain) with NFYA (via N-terminus) (PubMed:12741956). Interacts with EFNB1 intracellular domain peptide; the interaction enhances ZHX2 transcriptional repression activity (By similarity). {ECO:0000250|UniProtKB:Q8C0C0, ECO:0000269|PubMed:12741956, ECO:0000269|PubMed:14659886}.

Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:12741956, ECO:0000269|PubMed:17056598}. Note=Colocalizes with EFNB1 intracellular domain in the nucleus. {ECO:0000250|UniProtKB:Q8C0C0}.

Tissue specificity: Ubiquitously expressed. Expressed in podocytes. {ECO:0000269|PubMed:12741956, ECO:0000269|PubMed:17056598}.

Similarity: Belongs to the ZHX family. {ECO:0000305}.

Sequence caution: Sequence=BAA74877.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

Annotations taken from UniProtKB at the EBI.


Organism:		Homo sapiens (Human).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.



Function:		Acts as a transcriptional repressor (PubMed:12741956). Represses the promoter activity of the CDC25C gene stimulated by NFYA (PubMed:12741956). May play a role in retinal development where it regulates the composition of bipolar cell populations, by promoting differentiation of bipolar OFF-type cells (By similarity). In the brain, may promote maintenance and suppress differentiation of neural progenitor cells in the developing cortex (By similarity). {ECO:0000250\|UniProtKB:Q8C0C0, ECO:0000269\|PubMed:12741956}.


Subunit:		Homodimer (via homeobox domain) (PubMed:12741956, PubMed:14659886). Heterodimer with ZHX1 (via homeobox domain 1) (PubMed:12741956). Heterodimer with ZHX3 (via homeobox domain 1) (PubMed:12741956, PubMed:14659886). Heterodimerization with ZHX1 is not necessary for repressor activity (PubMed:12741956). Interacts (via homeobox domain) with NFYA (via N-terminus) (PubMed:12741956). Interacts with EFNB1 intracellular domain peptide; the interaction enhances ZHX2 transcriptional repression activity (By similarity). {ECO:0000250\|UniProtKB:Q8C0C0, ECO:0000269\|PubMed:12741956, ECO:0000269\|PubMed:14659886}.
Subcellular location:		Nucleus {ECO:0000255\|PROSITE-ProRule:PRU00108, ECO:0000269\|PubMed:12741956, ECO:0000269\|PubMed:17056598}. Note=Colocalizes with EFNB1 intracellular domain in the nucleus. {ECO:0000250\|UniProtKB:Q8C0C0}.
Tissue specificity:		Ubiquitously expressed. Expressed in podocytes. {ECO:0000269\|PubMed:12741956, ECO:0000269\|PubMed:17056598}.
Similarity:		Belongs to the ZHX family. {ECO:0000305}.
Sequence caution:		Sequence=BAA74877.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};