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UniProt functional annotation for P16732 | ||
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| UniProt code: P16732. |
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| Organism: | |
Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5). |
| Taxonomy: | |
Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes; Herpesvirales; Herpesviridae; Betaherpesvirinae; Cytomegalovirus. |
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| Function: | |
Component of the molecular motor that translocates viral genomic DNA in empty capsid during DNA packaging. Forms a tripartite terminase complex together with TRM1 and TRM2 in the host cytoplasm. Once the complex reaches the host nucleus, it interacts with the capsid portal vertex. This portal forms a ring in which genomic DNA is translocated into the capsid. TRM3 carries an RNase H-like nuclease activity that plays an important role for the cleavage of concatemeric viral DNA into unit length genomes. {ECO:0000255|HAMAP-Rule:MF_04013}. |
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| Subunit: | |
Interacts with the terminase subunits TRM1 and TRM2. Interacts with portal protein. {ECO:0000255|HAMAP-Rule:MF_04013, ECO:0000269|PubMed:16846228}. |
| Subcellular location: | |
Host nucleus {ECO:0000255|HAMAP-Rule:MF_04013}. Note=Responsible for the nuclear localization of the two others subunits TRM1 and TRM2. {ECO:0000255|HAMAP-Rule:MF_04013}. |
| Similarity: | |
Belongs to the herpesviridae TRM3 protein family. {ECO:0000255|HAMAP-Rule:MF_04013}. |
Annotations taken from UniProtKB at the EBI.