PDBsum entry 3mwy

Hydrolase

PDB id

3mwy

Loading ...

Contents

			Protein chain

					696 a.a. *

			Ligands

					AGS

* Residue conservation analysis

PDB id:

3mwy

Links

Name:

Hydrolase

Title:

Crystal structure of the chromodomain-atpase portion of the yeast chd1 chromatin remodeler

Structure:

Chromo domain-containing protein 1. Chain: w. Fragment: double chromodomains and atpase motor (unp residues 142- 939). Synonym: atp-dependent helicase chd1. Engineered: yes

Source:

Saccharomyces cerevisiae. Brewer's yeast,lager beer yeast,yeast. Organism_taxid: 4932. Gene: chd1, sygp-orf4, yer164w. Expressed in: escherichia coli. Expression_system_taxid: 469008.

Resolution:

3.70Å

R-factor:

0.265

R-free:

0.318

Authors:

G.Hauk,G.D.Bowman

Key ref:

G.Hauk et al. (2010). The chromodomains of the Chd1 chromatin remodeler regulate DNA access to the ATPase motor. Mol Cell, 39, 711-723. PubMed id: 20832723

Date:

06-May-10

Release date:

29-Sep-10

PROCHECK

	Headers

	References

Protein chain

P32657 (CHD1_YEAST) - Chromo domain-containing protein 1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c)

Seq: Struc:

Seq: Struc:

Seq: Struc:					1468 a.a. 696 a.a.

Key:

PfamA domain

Secondary structure

CATH domain



		Enzyme reactions

Enzyme class:

E.C.3.6.4.- - ?????

[IntEnz] [ExPASy] [KEGG] [BRENDA]

	Mol Cell 39:711-723 (2010)
PubMed id: 20832723

The chromodomains of the Chd1 chromatin remodeler regulate DNA access to the ATPase motor.
G.Hauk, J.N.McKnight, I.M.Nodelman, G.D.Bowman.

ABSTRACT

No abstract given.

Literature references that cite this PDB file's key reference

PubMed id

Reference

23288358

B.J.Manning, and C.L.Peterson (2013).
Releasing the brakes on a chromatin-remodeling enzyme.

Nat Struct Mol Biol, 20, 5-7.

23202585

F.Mueller-Planitz, H.Klinker, J.Ludwigsen, and P.B.Becker (2013).
The ATPase domain of ISWI is an autonomous nucleosome remodeling machine.

Nat Struct Mol Biol, 20, 82-89.

23143334

C.R.Clapier, and B.R.Cairns (2012).
Regulation of ISWI involves inhibitory modules antagonized by nucleosomal epitopes.

Nature, 492, 280-284.

21177652

S.Morettini, M.Tribus, A.Zeilner, J.Sebald, B.Campo-Fernandez, G.Scheran, H.Wörle, V.Podhraski, D.V.Fyodorov, and A.Lusser (2011).
The chromodomains of CHD1 are critical for enzymatic activity but less important for chromatin localization.

Nucleic Acids Res, 39, 3103-3115.

The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time.