PDBsum entry 3mw4

Cell adhesion

PDB id

3mw4

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Contents

			Protein chains

					178 a.a. *

			Ligands

					NAG-NAG-BMA ×3


					SO4 ×8

			Metals

					_CA

			Waters ×727

* Residue conservation analysis

PDB id:

3mw4

Links

Name:

Cell adhesion

Title:

Crystal structure of beta-neurexin 3 without the splice insert 4

Structure:

Neurexin-2-beta. Chain: a, b, c. Fragment: unp residues 854 to 1027. Synonym: neurexin iii-alpha. Engineered: yes

Source:

Mus musculus. Mouse. Organism_taxid: 10090. Gene: c14orf60, kiaa0743, mkiaa0743, nrxn3. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293

Resolution:

2.00Å

R-factor:

0.179

R-free:

0.215

Authors:

X.Jin,L.Shapiro

Key ref:

J.Koehnke et al. (2010). Splice form dependence of beta-neurexin/neuroligin binding interactions. Neuron, 67, 61-74. PubMed id: 20624592

Date:

05-May-10

Release date:

28-Jul-10

PROCHECK

	Headers

	References

Protein chains

Q6P9K9 (NRX3A_MOUSE) - Neurexin-3 from Mus musculus

Seq: Struc:

Seq: Struc:

Seq: Struc:

Seq: Struc:					1571 a.a. 178 a.a.*

Key:

PfamA domain

Secondary structure

CATH domain

* PDB and UniProt seqs differ at 3 residue positions (black crosses)

	Neuron 67:61-74 (2010)
PubMed id: 20624592

Splice form dependence of beta-neurexin/neuroligin binding interactions.
J.Koehnke, P.S.Katsamba, G.Ahlsen, F.Bahna, J.Vendome, B.Honig, L.Shapiro, X.Jin.

ABSTRACT

No abstract given.

Literature references that cite this PDB file's key reference

PubMed id

Reference

22902367

O.J.Harrison, J.Vendome, J.Brasch, X.Jin, S.Hong, P.S.Katsamba, G.Ahlsen, R.B.Troyanovsky, S.M.Troyanovsky, B.Honig, and L.Shapiro (2012).
Nectin ectodomain structures reveal a canonical adhesive interface.

Nat Struct Mol Biol, 19, 906-915.

PDB codes:

4fmf 4fmk 4fn0 4fom 4fqp 4frw 4fs0

21155806

G.J.Wright, and P.Washbourne (2011).
Neurexins, neuroligins and LRRTMs: synaptic adhesion getting fishy.

J Neurochem, 117, 765-778.

21342763

M.Yuzaki (2011).
Cbln1 and its family proteins in synapse formation and maintenance.

Curr Opin Neurobiol, 21, 215-220.

The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time. Where a reference describes a PDB structure, the PDB codes are shown on the right.