UniProt functional annotation for P03211



	UniProt functional annotation for P03211

UniProt code: P03211.

Organism: Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4).

Taxonomy: Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes; Herpesvirales; Herpesviridae; Gammaherpesvirinae; Lymphocryptovirus.

Function: Plays an essential role in replication and partitioning of viral genomic DNA during latent viral infection. During this phase, the circular double-stranded viral DNA undergoes replication once per cell cycle and is efficiently partitioned to the daughter cells. EBNA1 activates the initiation of viral DNA replication through binding to specific sites in the viral latent origin of replication, oriP. Additionally, it governs the segregation of viral episomes by mediating their attachment to host cell metaphase chromosomes. Also activates the transcription of several viral latency genes. Finally, it can counteract the stabilization of host p53/TP53 by host USP7, thereby decreasing apoptosis and increasing host cell survival. {ECO:0000269|PubMed:15808506, ECO:0000269|PubMed:31941781}.

Subunit: Interacts with human USP7. Interacts with human EBP2; this interaction is important for the stable segregation of EBV episomes during cell division but not for the replication of the episomes. Interacts with BGLF4; this interaction facilitates the switch from latent to lytic DNA replication by down-regulating EBNA1 replication function. Interacts with human PAX5; this interaction promotes EBNA1- dependent transcription. {ECO:0000269|PubMed:10074103, ECO:0000269|PubMed:14506283, ECO:0000269|PubMed:15808506, ECO:0000269|PubMed:19244323, ECO:0000269|PubMed:31941781}.

Subcellular location: Host nucleus {ECO:0000269|PubMed:2161150, ECO:0000269|PubMed:31941781}.

Similarity: Belongs to the herpesviridae EBNA1 family. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.


Organism:		Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4).
Taxonomy:		Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes; Herpesvirales; Herpesviridae; Gammaherpesvirinae; Lymphocryptovirus.



Function:		Plays an essential role in replication and partitioning of viral genomic DNA during latent viral infection. During this phase, the circular double-stranded viral DNA undergoes replication once per cell cycle and is efficiently partitioned to the daughter cells. EBNA1 activates the initiation of viral DNA replication through binding to specific sites in the viral latent origin of replication, oriP. Additionally, it governs the segregation of viral episomes by mediating their attachment to host cell metaphase chromosomes. Also activates the transcription of several viral latency genes. Finally, it can counteract the stabilization of host p53/TP53 by host USP7, thereby decreasing apoptosis and increasing host cell survival. {ECO:0000269\|PubMed:15808506, ECO:0000269\|PubMed:31941781}.


Subunit:		Interacts with human USP7. Interacts with human EBP2; this interaction is important for the stable segregation of EBV episomes during cell division but not for the replication of the episomes. Interacts with BGLF4; this interaction facilitates the switch from latent to lytic DNA replication by down-regulating EBNA1 replication function. Interacts with human PAX5; this interaction promotes EBNA1- dependent transcription. {ECO:0000269\|PubMed:10074103, ECO:0000269\|PubMed:14506283, ECO:0000269\|PubMed:15808506, ECO:0000269\|PubMed:19244323, ECO:0000269\|PubMed:31941781}.
Subcellular location:		Host nucleus {ECO:0000269\|PubMed:2161150, ECO:0000269\|PubMed:31941781}.
Similarity:		Belongs to the herpesviridae EBNA1 family. {ECO:0000305}.