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PDBsum entry 3mow
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Hydrolase/hydrolase inhibitor
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PDB id
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3mow
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PDB id:
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| Name: |
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Hydrolase/hydrolase inhibitor
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Title:
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Crystal structure of shp2 in complex with a tautomycetin analog ttn d- 1
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Structure:
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Tyrosine-protein phosphatase non-receptor type 11. Chain: a. Fragment: catalytic domain (unp residues 262-528). Synonym: protein-tyrosine phosphatase 2c, ptp-2c, protein-tyrosine phosphatase 1d, ptp-1d, sh-ptp3, sh-ptp2, shp-2, shp2. Engineered: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: ptp2c, ptpn11, shptp2. Expressed in: escherichia coli. Expression_system_taxid: 511693.
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Resolution:
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2.30Å
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R-factor:
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0.170
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R-free:
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0.222
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Authors:
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Z.-Y.Zhang,S.Liu,Z.Yu,X.Yu
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Key ref:
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Z.-Y.Zhang
et al.
Crystal structure of shp2 in complex with a tautomyce analog ttn d-1.
To be published,
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Date:
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23-Apr-10
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Release date:
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04-May-11
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PROCHECK
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Headers
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References
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Q06124
(PTN11_HUMAN) -
Tyrosine-protein phosphatase non-receptor type 11 from Homo sapiens
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Seq:
Struc:
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593 a.a.
254 a.a.
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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Enzyme class:
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E.C.3.1.3.48
- protein-tyrosine-phosphatase.
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Reaction:
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O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate
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O-phospho-L-tyrosyl-[protein]
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+
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H2O
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=
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L-tyrosyl-[protein]
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+
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phosphate
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Links
