PDBsum entry 3moq

Neuropeptide, immune system

PDB id: 3moq

Contents

Protein chains

126 a.a. *

Waters ×559

* Residue conservation analysis

PDB id:

3moq

Name:

Neuropeptide, immune system

Title:

Amyloid beta(18-41) peptide fusion with new antigen receptor variable domain from sharks

Structure:

New antigen receptor variable domain,p3(40) peptide from amyloid beta a4 protein,new antigen receptor variable domain. Chain: a, b, c, d. Synonym: abpp,appi,app,alzheimer disease amyloid protein,amyloid precursor protein,beta-amyloid precursor protein,cerebral vascular amyloid peptide,cvap,prea4,protease nexin-ii,pn-ii. Engineered: yes. Other_details: chimera of new antigen receptor variable domain (residues 1-87 and 102-113 from unp q6x1e6) inserted with amyloid

Source:

Orectolobus maculatus, homo sapiens. Spotted wobbegong, human. Organism_taxid: 168098, 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.

Resolution:

2.05Å R-factor: 0.193 R-free: 0.249

Authors:

V.A.Streltsov

Key ref:

V.A.Streltsov et al. (2011). Crystal structure of the amyloid-β p3 fragment provides a model for oligomer formation in Alzheimer's disease. J Neurosci, 31, 1419-1426. PubMed id: 21273426

Date:

23-Apr-10 Release date: 16-Feb-11

Protein chains

P05067  (A4_HUMAN) -  Amyloid-beta precursor protein from Homo sapiens

Seq: 770 a.a.

Struc: 126 a.a.*

Protein chains

Q6X1E6  (Q6X1E6_9CHON) -  New antigen receptor variable domain (Fragment) from Orectolobus maculatus

Seq: 113 a.a.

Struc: 126 a.a.*

* PDB and UniProt seqs differ at 117 residue positions (black crosses)

J Neurosci 31:1419-1426 (2011)

PubMed id: 21273426

Crystal structure of the amyloid-β p3 fragment provides a model for oligomer formation in Alzheimer's disease.

V.A.Streltsov, J.N.Varghese, C.L.Masters, S.D.Nuttall.

ABSTRACT

No abstract given.