PDBsum entry 3mhw

Hydrolase

PDB id: 3mhw

Contents

Protein chain

246 a.a. *

Ligands

SO4

ABV

Waters ×182

* Residue conservation analysis

PDB id:

3mhw

Name:

Hydrolase

Title:

The complex crystal structure of urokianse and 2-aminobenzothiazole

Structure:

Urokinase-type plasminogen activator. Chain: u. Fragment: c-terminal domain, unp residues 179-425. Synonym: u-plasminogen activator, upa, urokinase-type plasminogen activator chain b. Engineered: yes. Mutation: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: human. Expressed in: pichia pastoris. Expression_system_taxid: 4922.

Resolution:

1.45Å R-factor: 0.206 R-free: 0.234

Authors:

L.-G.Jiang,C.Yuan,L.-Q.Chen,M.-D.Huang

Key ref:

L.-G.Jiang et al. (2009). Crystal structures of 2-Aminobenzothiazole-Based inhibitors in complexes with urokinase-Type plasminogen activator. Chin j struct chem, 28, 1427.

Date:

09-Apr-10 Release date: 21-Apr-10

Protein chain

P00749  (UROK_HUMAN) -  Urokinase-type plasminogen activator from Homo sapiens

Seq: 431 a.a.

Struc: 246 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class: E.C.3.4.21.73 - u-plasminogen activator.
• Reaction: Specific cleavage of Arg-|-Val bond in plasminogen to form plasmin.