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Ligand clusters for UniProt code Q05769

Ligand clusters for Q05769: Prostaglandin G/H synthase 2 OS=Mus musculus GN=Ptgs2 PE=1 SV=1

Top 6 (of 24) ligand clusters
Cluster 1.
34 ligand types
60 ligands
Cluster 2.
6 ligand types
46 ligands
Cluster 3.
6 ligand types
38 ligands
Cluster 4.
4 ligand types
38 ligands
Cluster 5.
4 ligand types
42 ligands
Cluster 6.
1 ligand type
5 ligands
Representative protein: 4rs0A  
 

Structures

PDB   Schematic diagram
4rs0A    
3mqeA    
1cvuA    
3ln0A    
3qmoA    
 more ...

 

 Cluster 1 contains 34 ligand types (of which only 20 are listed. Click for all)

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Ligand Description


 
1. Ligand: PGX × 1
7-[6-(3-Hydroperoxy-Oct-1-Enyl)-2,3-Dioxa- Bicyclo[2.2.1]hept-5-Yl]-Hept-5-Enoic acid
PDB code: 1ddx(A).


 
2. Ligand: LUR × 4
lumiracoxib
{2-[(2-Chloro-6-Fluorophenyl)amino]-5- Methylphenyl}acetic acid
PDB codes: 4oty(A), 4rrw(A), 4rrx(A), 4rrz(A).


 
3. Ligand: CEL × 2
celecoxib
4-[5-(4-Methylphenyl)-3-(Trifluoromethyl)-1h-Pyrazol-1- Yl]benzenesulfonamide
PDB codes: 3ln1(A), 5jw1(A).


 
4. Ligand: FLP × 2
flurbiprofen
Flurbiprofen
PDB codes: 3pgh(A), 5jvz(A).


 
5. Ligand: IBP × 2
ibuprofen
Ibuprofen
PDB codes: 4ph9(A), 4rs0(A).


 
6. Ligand: DIF × 1
diclofenac
2-[2,6-Dichlorophenyl)amino]benzeneacetic acid
PDB code: 1pxx(A).


 
7. Ligand: EPA × 1
icosapent
5,8,11,14,17-Eicosapentaenoic acid
PDB code: 3hs6(A).


 
8. Ligand: IMN × 1
indomethacin
Indomethacin
PDB code: 4cox(A).


 
9. Ligand: LNL × 1
alpha-linolenic acid
Alpha-Linolenic acid
PDB code: 4e1g(A).


 
10. Ligand: MXM × 1
meloxicam
4-Hydroxy-2-Methyl-N-(5-Methyl-1,3-Thiazol-2-Yl)-2h-1, 2-Benzothiazine-3-Carboxamide 1,1-Dioxide
PDB code: 4m11(A).


 
11. Ligand: NPS × 1
naproxen
(2s)-2-(6-Methoxynaphthalen-2-Yl)propanoic acid
PDB code: 3nt1(A).


 
12. Ligand: S58 × 1
1-Phenylsulfonamide-3-Trifluoromethyl-5- Parabromophenylpyrazole
PDB code: 6cox(A).


 
13. Ligand: BOG × 9
B-Octylglucoside
PDB codes: 3nt1(A), 3ntb(A), 3q7d(A), 3rr3(A), 4fm5(A), 4ph9(A), 4rry(A), 4rs0(A), 5jvz(A).


 
14. Ligand: EDO × 7
1,2-Ethanediol
PDB codes: 3hs5(A), 3hs6(A), 3hs7(A), 3olt(A), 3olu(A), 3qh0(A), 4ph9(A).


 
15. Ligand: ACD × 5
Arachidonic acid
PDB codes: 1cvu(A), 3hs5(A), 3krk(A), 3olt(A), 3tzi(A).


 
16. Ligand: 1AG × 2
(2s)-2,3-Dihydroxypropyl (5z,8z,11z,14z)-Icosa-5,8,11, 14-Tetraenoate
PDB codes: 3mdl(A), 3olu(A).


 
17. Ligand: S58 × 1
1-Phenylsulfonamide-3-Trifluoromethyl-5- Parabromophenylpyrazole
PDB code: 1cx2(A).

_Cl
 
18. Metal: _CL × 2
PDB codes: 3nt1(A), 3q7d(A).


 
19. Ligand: 416 × 1
(2s)-7-Tert-Butyl-6-Chloro-2-(Trifluoromethyl)-2h- Chromene-3-Carboxylic acid
PDB code: 3mqe(A).


 
20. Ligand: 4LA × 1
(R)-7-{[5-Methoxy-2-Methyl-3-(Methoxycarbonylmethyl)- 1h-Indolyl]carbonyl}-7,8-Dicarba-Nido-Dodeca-
Hydroundecaborate
PDB code: 4z0l(A).

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 Cluster 2 contains 6 ligand types

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Ligand Description


 
1. Ligand: NAG × 10
n-acetyl-d-glucosamine
N-Acetyl-D-Glucosamine
PDB codes: 1cx2(A), 1ddx(A), 3pgh(A), 3q7d(A), 3rr3(A), 4cox(A), 5cox(A), 6cox(A).


 
2. Ligand: NAG-NAG × 19
NAG=N-Acetyl-D-Glucosamine.
PDB codes: 3krk(A), 3nt1(A), 3ntg(A), 3qmo(A), 4fm5(A), 4m10(A), 4m11(A), 4otj(A), 4oty(A), 4ph9(A), 4rrw(A), 4rrx(A), 4rry(A), 4rrz(A), 4rs0(A), 4rut(A), 4z0l(A), 5jvy(A), 5jw1(A).


 
3. Ligand: NAG-NAG-MAN × 10
NAG=N-Acetyl-D-Glucosamine, MAN=Alpha-D-Mannose.
PDB codes: 3hs5(A), 3hs6(A), 3hs7(A), 3mdl(A), 3olt(A), 3olu(A), 3qh0(A), 3tzi(A), 4e1g(A), 5fdq(A).


 
4. Ligand: NAG-NAG-NAG × 5
NAG=N-Acetyl-D-Glucosamine.
PDB codes: 1pxx(A), 3ln0(A), 3ln1(A), 3mqe(A), 3ntb(A).


 
5. Ligand: NAG-NAG-BMA × 1
NAG=N-Acetyl-D-Glucosamine, BMA=Beta-D-Mannose.
PDB code: 5jvz(A).


 
6. Ligand: NAG-NAG-MAN-MAN × 1
NAG=N-Acetyl-D-Glucosamine, MAN=Alpha-D-Mannose.
PDB code: 1cvu(A).

 

 Cluster 3 contains 6 ligand types

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Ligand Description


 
1. Ligand: NAG × 6
n-acetyl-d-glucosamine
N-Acetyl-D-Glucosamine
PDB codes: 1cx2(A), 3pgh(A), 3q7d(A), 3rr3(A), 4cox(A).


 
2. Ligand: NAG-NAG × 21
NAG=N-Acetyl-D-Glucosamine.
PDB codes: 3hs5(A), 3hs6(A), 3hs7(A), 3mdl(A), 3nt1(A), 3ntg(A), 3qh0(A), 3tzi(A), 4e1g(A), 4fm5(A), 4m10(A), 4m11(A), 4oty(A), 4rrw(A), 4rrx(A), 4rry(A), 4rrz(A), 4z0l(A), 5fdq(A), 5jvz(A), 5jw1(A).


 
3. Ligand: NAG-NAG-NAG × 5
NAG=N-Acetyl-D-Glucosamine.
PDB codes: 1pxx(A), 3ln0(A), 3ln1(A), 3mqe(A), 3ntb(A).


 
4. Ligand: NAG-NAG-MAN × 4
NAG=N-Acetyl-D-Glucosamine, MAN=Alpha-D-Mannose.
PDB codes: 3krk(A), 3olt(A), 4ph9(A), 5jvy(A).


 
5. Ligand: NAG-NAG-BMA × 1
NAG=N-Acetyl-D-Glucosamine, BMA=Beta-D-Mannose.
PDB code: 3qmo(A).


 
6. Ligand: NAG-NAG-MAN-MAN × 1
NAG=N-Acetyl-D-Glucosamine, MAN=Alpha-D-Mannose.
PDB code: 1cvu(A).

 

 Cluster 4 contains 4 ligand types

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Ligand Description


 
1. Ligand: HEM × 21
Protoporphyrin IX containing fe
PDB codes: 1pxx(A), 3pgh(A), 4cox(A), 5cox(A), 6cox(A), 1cx2(A), 3ln0(A), 3ln1(A), 3mqe(A), 3nt1(A), 3ntb(A), 3ntg(A), 3q7d(A), 3qmo(A), 3rr3(A), 4fm5(A), 4m10(A), 4m11(A), 4otj(A), 4ph9(A), 4z0l(A).


 
2. Ligand: COH × 15
Protoporphyrin IX containing co
PDB codes: 3hs5(A), 3hs6(A), 3hs7(A), 3krk(A), 3mdl(A), 3olt(A), 3olu(A), 3qh0(A), 3tzi(A), 4e1g(A), 4rut(A), 5fdq(A), 5jvy(A), 5jvz(A), 5jw1(A).


 
3. Ligand: BOG × 1
B-Octylglucoside
PDB code: 1cvu(A).


 
4. Ligand: GOL × 1
Glycerol
PDB code: 3qmo(A).

 

 Cluster 5 contains 4 ligand types

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Ligand Description


 
1. Ligand: NAG × 28
n-acetyl-d-glucosamine
N-Acetyl-D-Glucosamine
PDB codes: 1cx2(A), 1pxx(A), 3ln0(A), 3ln1(A), 3mqe(A), 3nt1(A), 3ntb(A), 3pgh(A), 3q7d(A), 3rr3(A), 4cox(A), 4m10(A), 4m11(A), 4otj(A), 4oty(A), 4ph9(A), 4rrw(A), 4rrx(A), 4rry(A), 4rrz(A), 4rs0(A), 4rut(A), 4z0l(A), 5cox(A), 5jvy(A), 5jvz(A), 5jw1(A), 6cox(A).


 
2. Ligand: NAG-NAG × 12
NAG=N-Acetyl-D-Glucosamine.
PDB codes: 1cvu(A), 1ddx(A), 3hs5(A), 3hs6(A), 3hs7(A), 3krk(A), 3mdl(A), 3olt(A), 3olu(A), 3tzi(A), 4e1g(A), 5fdq(A).


 
3. Ligand: HSQ-NAG × 1
HSQ=2-(Acetylamino)-2-Deoxy-Alpha-L-Idopyranose, NAG=N-Acetyl-D-Glucosamine.
PDB code: 3qh0(A).


 
4. Ligand: NAG-NDG × 1
NAG=N-Acetyl-D-Glucosamine, NDG=2-(Acetylamino)-2-Deoxy-A-D-Glucopyranose.
PDB code: 3qmo(A).

 

 Cluster 6 contains 1 ligand type

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Ligand Description


 
1. Ligand: BOG × 5
B-Octylglucoside
PDB codes: 1ddx(A), 1cvu(A), 3nt1(A), 3q7d(A), 4rrx(A).

 

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