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UniProt functional annotation for Q9NQT8 | ||
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| UniProt code: Q9NQT8. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Involved in reorganization of the cortical cytoskeleton. Regulates axon formation by promoting the formation of extra axons. May be functionally important for the intracellular trafficking of MAGUKs and associated protein complexes. {ECO:0000269|PubMed:20194617}. |
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| Subunit: | |
Binds to DLG1 and DLG4. Interacts (when phosphorylated at Ser- 1381 and Ser-1410) with 14-3-3. {ECO:0000269|PubMed:10859302, ECO:0000269|PubMed:20194617}. |
| Subcellular location: | |
Cytoplasm, cytoskeleton {ECO:0000269|PubMed:20194617}. Cell projection, axon {ECO:0000269|PubMed:20194617}. Note=accumulates at the distal part of the microtubules in the tips of axons, but not of dendrites. |
| Tissue specificity: | |
Ubiquitous. |
| Ptm: | |
Phosphorylated at Ser-1381 and Ser-1410 by MARK2, promoting interaction with 14-3-3 and inhibiting microtubule-dependent accumulation and formation of axons. {ECO:0000269|PubMed:20194617}. |
| Similarity: | |
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. {ECO:0000255|PROSITE-ProRule:PRU00283}. |
| Sequence caution: | |
Sequence=BAA31614.3; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; |
Annotations taken from UniProtKB at the EBI.