PDBsum entry 3mdb

Transport protein/hydrolase activator

PDB id: 3mdb

Contents

Protein chains

98 a.a. *

365 a.a. *

Ligands

UNX ×11

IP9

Metals

_ZN ×2

* Residue conservation analysis

PDB id:

3mdb

Name:

Transport protein/hydrolase activator

Title:

Crystal structure of the ternary complex of full length centaurin alpha-1, kif13b fha domain, and ip4

Structure:

Kinesin-like protein kif13b. Chain: a, b. Fragment: fha domain (unp residues 440 to 545). Synonym: kinesin-like protein gakin. Engineered: yes. Arf-gap with dual ph domain-containing protein 1. Chain: c, d. Synonym: centaurin-alpha-1, cnt-a1, putative mapk-activating protein pm25.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: kif13b, gakin, kiaa0639. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: adap1, centa1.

Resolution:

2.95Å R-factor: 0.227 R-free: 0.277

Authors:

L.Shen,Y.Tong,W.Tempel,F.Mackenzie,C.H.Arrowsmith,A.M.Edwards, C.Bountra,J.Weigelt,A.Bochkarev,H.Park,Structural Genomics Consortium (Sgc)

Key ref:

L.Shen et al. Crystal structure of the ternary complex of full leng centaurin alpha-1, Kif13b fha domain, And ip4. To be published, .

Date:

30-Mar-10 Release date: 04-Aug-10

Protein chains

Q9NQT8  (KI13B_HUMAN) -  Kinesin-like protein KIF13B from Homo sapiens

Seq: 1826 a.a.

Struc: 98 a.a.

Protein chains

O75689  (ADAP1_HUMAN) -  Arf-GAP with dual PH domain-containing protein 1 from Homo sapiens

Seq: 374 a.a.

Struc: 365 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)