PDBsum entry 3mcl

Immune system

PDB id: 3mcl

Contents

Protein chains

209 a.a. *

228 a.a. *

Waters ×496

* Residue conservation analysis

PDB id:

3mcl

Name:

Immune system

Title:

Anti-beta-amyloid antibody c706 fab in space group p21

Structure:

C706 monoclonal light chain. Chain: l. Fragment: chimeric molecule of mouse variable domain and human constant domain. Engineered: yes. C706 monoclonal heavy chain. Chain: h. Fragment: fd fragment of the heavy chain, chimeric molecule of mouse variable domain and human constant domain.

Source:

Mus musculus, homo sapiens. Mouse,human. Organism_taxid: 10090,9606. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell: human embryonic kidney (hek) 293 cells. Mouse, human. Expression_system_cell: human embryonic kidney (hek) 293 cells

Resolution:

1.70Å R-factor: 0.205 R-free: 0.260

Authors:

A.Teplyakov,G.Obmolova,G.L.Gilliland

Key ref:

A.Teplyakov et al. (2011). His-tag binding by antibody C706 mimics β-amyloid recognition. J Mol Recognit, 24, 570-575. PubMed id: 20842634

Date:

29-Mar-10 Release date: 24-Nov-10

Protein chain

No UniProt id for this chain

Struc: 209 a.a.

Protein chain

P01857  (IGHG1_HUMAN) -  Immunoglobulin heavy constant gamma 1 from Homo sapiens

Seq: 399 a.a.

Struc: 228 a.a.*

* PDB and UniProt seqs differ at 5 residue positions (black crosses)

J Mol Recognit 24:570-575 (2011)

PubMed id: 20842634

His-tag binding by antibody C706 mimics β-amyloid recognition.

A.Teplyakov, G.Obmolova, G.Canziani, Y.Zhao, L.Gutshall, S.S.Jung, G.L.Gilliland.

ABSTRACT

No abstract given.