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PDBsum entry 3m5s

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protein ligands metals links
Lyase PDB id
3m5s
Jmol PyMol
Contents
Protein chain
257 a.a.
Ligands
CO3
Metals
_ZN
Waters ×177
PDB id:
3m5s
Name: Lyase
Title: Carbonic anhydrase ii mutant h64c in complex with carbonate
Structure: Carbonic anhydrase 2. Chain: a. Fragment: carbonic anhydrase ii. Synonym: carbonic anhydrase ii, ca-ii, carbonate dehydratas carbonic anhydrasE C, cac. Engineered: yes. Mutation: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ca2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Resolution:
1.40Å     R-factor:   0.138     R-free:   0.179
Authors: J.Schulze Wischeler,A.Heine,G.Klebe
Key ref: J.Schulze wischeler et al. Mutational study on carbonic anhydrase ii. To be published, .
Date:
13-Mar-10     Release date:   25-May-11    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
P00918  (CAH2_HUMAN) -  Carbonic anhydrase 2
Seq:
Struc:
260 a.a.
257 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 1 residue position (black cross)

 Enzyme reactions 
   Enzyme class: E.C.4.2.1.1  - Carbonic anhydrase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: H2CO3 = CO2 + H2O
H(2)CO(3)
Bound ligand (Het Group name = CO3)
corresponds exactly
= CO(2)
+ H(2)O
      Cofactor: Zn(2+)
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     extracellular space   11 terms 
  Biological process     angiotensin-mediated signaling pathway   22 terms 
  Biochemical function     protein binding     6 terms  

 

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