UniProt functional annotation for B7NY59



	UniProt functional annotation for B7NY59

UniProt code: B7NY59.

Organism: Influenza A virus (A/chicken/New Jersey/Sg-00421/2004(H7N2)).

Taxonomy: Viruses; Riboviria; Orthornavirae; Negarnaviricota; Polyploviricotina; Insthoviricetes; Articulavirales; Orthomyxoviridae; Alphainfluenzavirus.

Function: Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore. {ECO:0000256|RuleBase:RU003324}.

Subunit: Homotrimer of disulfide-linked HA1-HA2. {ECO:0000256|RuleBase:RU003324}.

Subcellular location: Apical cell membrane {ECO:0000256|ARBA:ARBA00004247}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004247}. Cell membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}. Host apical cell membrane {ECO:0000256|ARBA:ARBA00004310}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004310}. Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.

Similarity: Belongs to the influenza viruses hemagglutinin family. {ECO:0000256|ARBA:ARBA00006321, ECO:0000256|RuleBase:RU003324}.

Annotations taken from UniProtKB at the EBI.


Organism:		Influenza A virus (A/chicken/New Jersey/Sg-00421/2004(H7N2)).
Taxonomy:		Viruses; Riboviria; Orthornavirae; Negarnaviricota; Polyploviricotina; Insthoviricetes; Articulavirales; Orthomyxoviridae; Alphainfluenzavirus.



Function:		Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore. {ECO:0000256\|RuleBase:RU003324}.


Subunit:		Homotrimer of disulfide-linked HA1-HA2. {ECO:0000256\|RuleBase:RU003324}.
Subcellular location:		Apical cell membrane {ECO:0000256\|ARBA:ARBA00004247}; Single-pass type I membrane protein {ECO:0000256\|ARBA:ARBA00004247}. Cell membrane {ECO:0000256\|ARBA:ARBA00004251}; Single-pass type I membrane protein {ECO:0000256\|ARBA:ARBA00004251}. Host apical cell membrane {ECO:0000256\|ARBA:ARBA00004310}; Single-pass type I membrane protein {ECO:0000256\|ARBA:ARBA00004310}. Membrane {ECO:0000256\|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256\|ARBA:ARBA00004479}.
Similarity:		Belongs to the influenza viruses hemagglutinin family. {ECO:0000256\|ARBA:ARBA00006321, ECO:0000256\|RuleBase:RU003324}.