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UniProt functional annotation for Q9Y2Y4 | ||
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| UniProt code: Q9Y2Y4. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
DNA-binding protein that binds to the to a 5'-TGTACAGTGT-3' core sequence. May function as a transcriptional transactivator and transcriptional repressor. Probably exerts its repressor effect by preventing GATA3 from binding to DNA. May play a role in regulating the differentiation and activation of helper T-cells (By similarity). {ECO:0000250, ECO:0000269|PubMed:10572087}. |
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| Subunit: | |
Homodimer (via PTB domain). Interacts with the N-terminal of FANCC. Interacts with ZBTB16. Interacts with GATA3 (By similarity). {ECO:0000250}. |
| Subcellular location: | |
Nucleus {ECO:0000269|PubMed:10572087}. Note=Located in nuclear speckles. |
| Tissue specificity: | |
Predominantly expressed in testis. Some isoforms are ubiquitously expressed. {ECO:0000269|PubMed:10544010}. |
| Domain: | |
The C-terminal zinc finger domain functions as a transcriptional transactivator. {ECO:0000250}. |
| Domain: | |
The BTB (POZ) domain possesses repressor activity. {ECO:0000250}. |
| Similarity: | |
Belongs to the krueppel C2H2-type zinc-finger protein family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.