spacer
spacer

PDBsum entry 3ly5

Go to PDB code: 
protein ligands metals Protein-protein interface(s) links
Hydrolase PDB id
3ly5
Jmol PyMol
Contents
Protein chain
211 a.a. *
Ligands
PO4
SCN ×2
Metals
_MG ×2
Waters ×45
* Residue conservation analysis
PDB id:
3ly5
Name: Hydrolase
Title: Ddx18 dead-domain
Structure: Atp-dependent RNA helicase ddx18. Chain: a, b. Fragment: dead-domain, residues 149-387. Synonym: dead box protein 18, myc-regulated dead box protei engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ddx18. Expressed in: escherichia coli. Expression_system_taxid: 562.
Resolution:
2.80Å     R-factor:   0.247     R-free:   0.274
Authors: P.Schutz,T.Karlberg,C.H.Arrowsmith,H.Berglund,C.Bountra,R.Co A.M.Edwards,S.Flodin,A.Flores,S.Graslund,M.Hammarstrom,A.Jo I.Johansson,A.Kallas,P.Kraulis,T.Kotenyova,A.Kotzsch,N.Mark M.Moche,T.K.Nielsen,P.Nordlund,T.Nyman,C.Persson,A.K.Roos, M.I.Siponen,L.Svensson,A.G.Thorsell,L.Tresaugues,S.Van Den E.Wahlberg,J.Weigelt,M.Welin,M.Wisniewska,H.M.Schuler,Struc Genomics Consortium (Sgc)
Key ref: P.Schütz et al. (2010). Comparative structural analysis of human DEAD-box RNA helicases. PLoS One, 5, 12791-12791. PubMed id: 20941364
Date:
26-Feb-10     Release date:   12-May-10    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chains
Pfam   ArchSchema ?
Q9NVP1  (DDX18_HUMAN) -  ATP-dependent RNA helicase DDX18
Seq:
Struc:
 
Seq:
Struc:
670 a.a.
211 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.3.6.4.13  - Rna helicase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: ATP + H2O = ADP + phosphate
ATP
+ H(2)O
= ADP
+
phosphate
Bound ligand (Het Group name = PO4)
corresponds exactly
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Biochemical function     nucleic acid binding     2 terms  

 

 
    reference    
 
 
PLoS One 5:12791-12791 (2010)
PubMed id: 20941364  
 
 
Comparative structural analysis of human DEAD-box RNA helicases.
P.Schütz, T.Karlberg, S.van den Berg, R.Collins, L.Lehtiö, M.Högbom, L.Holmberg-Schiavone, W.Tempel, H.W.Park, M.Hammarström, M.Moche, A.G.Thorsell, H.Schüler.
 
  ABSTRACT  
 
No abstract given.

 

Literature references that cite this PDB file's key reference

  PubMed id Reference
22940866 A.L.Mallam, M.Del Campo, B.Gilman, D.J.Sidote, and A.M.Lambowitz (2012).
Structural basis for RNA-duplex recognition and unwinding by the DEAD-box helicase Mss116p.
  Nature, 490, 121-125.
PDB codes: 4db2 4db4
The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time. Where a reference describes a PDB structure, the PDB codes are shown on the right.

 

spacer

spacer