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PDBsum entry 3lxj

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protein ligands Protein-protein interface(s) links
Hydrolase PDB id
3lxj

 

 

 

 

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Contents
Protein chains
135 a.a. *
Ligands
IPA ×5
Waters ×136
* Residue conservation analysis
PDB id:
3lxj
Name: Hydrolase
Title: Crystal structure of the bromodomain of human aaa domain containing 2b (atad2b)
Structure: Atpase family aaa domain-containing protein 2b. Chain: a, b, c, d. Fragment: bromodomain. Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: atad2b, kiaa1240. Expressed in: escherichia coli. Expression_system_taxid: 562.
Resolution:
2.33Å     R-factor:   0.214     R-free:   0.253
Authors: P.Filippakopoulos,T.Keates,S.Picaud,O.Fedorov,T.Krojer,M.Vollmar, J.Muniz,A.C.W.Pike,F.Von Delft,C.H.Arrowsmith,A.Edwards,J.Weigelt, C.Bountra,S.Knapp,Structural Genomics Consortium (Sgc)
Key ref: P.Filippakopoulos et al. (2012). Histone recognition and large-scale structural analysis of the human bromodomain family. Cell, 149, 214-231. PubMed id: 22464331
Date:
25-Feb-10     Release date:   09-Mar-10    
PROCHECK
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 Headers
 References

Protein chains
Q9ULI0  (ATD2B_HUMAN) -  ATPase family AAA domain-containing protein 2B from Homo sapiens
Seq:
Struc:
 
Seq:
Struc:
 
Seq:
Struc:
1458 a.a.
135 a.a.*
Key:    Secondary structure  CATH domain
* PDB and UniProt seqs differ at 1 residue position (black cross)

 

 
Cell 149:214-231 (2012)
PubMed id: 22464331  
 
 
Histone recognition and large-scale structural analysis of the human bromodomain family.
P.Filippakopoulos, S.Picaud, M.Mangos, T.Keates, J.P.Lambert, D.Barsyte-Lovejoy, I.Felletar, R.Volkmer, S.Müller, T.Pawson, A.C.Gingras, C.H.Arrowsmith, S.Knapp.
 
  ABSTRACT  
 
No abstract given.

 

Literature references that cite this PDB file's key reference

  PubMed id Reference
23211769 C.A.Musselman, M.E.Lalonde, J.Côté, and T.G.Kutateladze (2012).
Perceiving the epigenetic landscape through histone readers.
  Nat Struct Mol Biol, 19, 1218-1227.  
The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time.

 

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