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PDBsum entry 3lrq
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Contents |
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* Residue conservation analysis
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PDB id:
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Ligase
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Title:
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Crystal structure of the u-box domain of human ubiquitin-protein ligase (e3), northeast structural genomics consortium target hr4604d.
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Structure:
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E3 ubiquitin-protein ligase trim37. Chain: a, b, c, d. Fragment: residues 1-90. Synonym: tripartite motif-containing protein 37, mulibrey nanism protein. Engineered: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: kiaa0898, mul, pob1, trim37. Expressed in: escherichia coli. Expression_system_taxid: 469008.
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Resolution:
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2.29Å
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R-factor:
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0.193
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R-free:
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0.245
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Authors:
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A.Kuzin,Y.Chen,J.Seetharaman,M.Mao,R.Xiao,C.Ciccosanti,R.Shastry, J.K.Everett,R.Nair,T.B.Acton,B.Rost,G.T.Montelione,L.Tong,J.F.Hunt, Northeast Structural Genomics Consortium (Nesg)
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Key ref:
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A.Kuzin
et al.
E3 ubiquitin-Protein ligase ring domain from human tripartite motif-Containing protein 37 (trim37), Nort structural genomics consortium target hr4604d..
To be published,
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Date:
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11-Feb-10
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Release date:
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23-Mar-10
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PROCHECK
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Headers
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References
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O94972
(TRI37_HUMAN) -
E3 ubiquitin-protein ligase TRIM37 from Homo sapiens
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Seq:
Struc:
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964 a.a.
82 a.a.
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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Enzyme class:
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E.C.2.3.2.27
- RING-type E3 ubiquitin transferase.
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Reaction:
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S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6- ubiquitinyl-[acceptor protein]-L-lysine
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Links
