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PDBsum entry 3lqm
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Protein binding
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PDB id
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3lqm
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References listed in PDB file
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Key reference
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Title
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Structure and mechanism of receptor sharing by the il-10r2 common chain.
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Authors
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S.I.Yoon,
B.C.Jones,
N.J.Logsdon,
B.D.Harris,
A.Deshpande,
S.Radaeva,
B.A.Halloran,
B.Gao,
M.R.Walter.
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Ref.
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Structure, 2010,
18,
638-648.
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PubMed id
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Abstract
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IL-10R2 is a shared cell surface receptor required for the activation of five
class 2 cytokines (IL-10, IL-22, IL-26, IL-28, and IL-29) that play critical
roles in host defense. To define the molecular mechanisms that regulate its
promiscuous binding, we have determined the crystal structure of the IL-10R2
ectodomain at 2.14 A resolution. IL-10R2 residues required for binding were
identified by alanine scanning and used to derive computational models of
IL-10/IL-10R1/IL-10R2 and IL-22/IL-22R1/IL-10R2 ternary complexes. The models
reveal a conserved binding epitope that is surrounded by two clefts that
accommodate the structural and chemical diversity of the cytokines. These
results provide a structural framework for interpreting IL-10R2 single
nucleotide polymorphisms associated with human disease.
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