 |
PDBsum entry 3lex
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Immune system
|
PDB id
|
|
|
|
3lex
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
 |
Contents |
 |
|
|
|
|
|
|
|
|
|
|
|
|
* Residue conservation analysis
|
|
|
|
|
|
PDB id:
|
|
|
|
| Name: |
|
Immune system
|
|
|
Title:
|
|
2f5 epitope scaffold elicited anti-HIV-1 monoclonal antibody 11f10 in complex with HIV-1 gp41
|
|
Structure:
|
|
11f10 antibody heavy chain. Chain: h, a. 11f10 antibody light chain. Chain: l, b. Envelope glycoprotein gp41. Chain: p, c. Engineered: yes
|
|
Source:
|
|
Mus musculus. Mouse. Organism_taxid: 10090. Strain: balb/c. Cell_line: myeloma cell line fo. Cell: hybridoma. Synthetic: yes. Human immunodeficiency virus 1. Organism_taxid: 11676.
|
|
Resolution:
|
|
|
1.97Å
|
R-factor:
|
0.166
|
R-free:
|
0.198
|
|
|
Authors:
|
|
G.Ofek,F.J.Guenaga,W.R.Schief,J.Skinner,D.Baker,R.Wyatt,P.D.Kwong
|
|
Key ref:
|
|
G.Ofek
et al.
(2010).
Elicitation of structure-specific antibodies by epitope scaffolds.
Proc Natl Acad Sci U S A,
107,
17880-17887.
PubMed id:
|
|
|
Date:
|
|
|
15-Jan-10
|
Release date:
|
29-Sep-10
|
|
|
|
|
|
|
PROCHECK
|
|
|
|
|
|
Headers
|
|
|
|
References
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
 |
|
|
|
|
|
|
| |
|
|
Proc Natl Acad Sci U S A
107:17880-17887
(2010)
|
|
PubMed id:
|
|
|
|
|
|
| |
|
Elicitation of structure-specific antibodies by epitope scaffolds.
|
|
G.Ofek,
F.J.Guenaga,
W.R.Schief,
J.Skinner,
D.Baker,
R.Wyatt,
P.D.Kwong.
|
|
|
|
|
| |
ABSTRACT
|
|
|
|
| |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
 |
 |
 |
|
Literature references that cite this PDB file's key reference
|
|
|
| |
PubMed id
|
|
Reference
|
|
|
|
|
|
J.Huang,
G.Ofek,
L.Laub,
M.K.Louder,
N.A.Doria-Rose,
N.S.Longo,
H.Imamichi,
R.T.Bailer,
B.Chakrabarti,
S.K.Sharma,
S.M.Alam,
T.Wang,
Y.Yang,
B.Zhang,
S.A.Migueles,
R.Wyatt,
B.F.Haynes,
P.D.Kwong,
J.R.Mascola,
and
M.Connors
(2012).
Broad and potent neutralization of HIV-1 by a gp41-specific human antibody.
|
| |
Nature,
491,
406-412.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
B.S.Graham
(2011).
Biological challenges and technological opportunities for respiratory syncytial virus vaccine development.
|
| |
Immunol Rev,
239,
149-166.
|
|
|
|
|
|
|
F.Breden,
C.Lepik,
N.S.Longo,
M.Montero,
P.E.Lipsky,
and
J.K.Scott
(2011).
Comparison of antibody repertoires produced by HIV-1 infection, other chronic and acute infections, and systemic autoimmune disease.
|
| |
PLoS One,
6,
e16857.
|
|
|
|
|
|
|
M.Kim,
Z.Y.Sun,
K.D.Rand,
X.Shi,
L.Song,
Y.Cheng,
A.F.Fahmy,
S.Majumdar,
G.Ofek,
Y.Yang,
P.D.Kwong,
J.H.Wang,
J.R.Engen,
G.Wagner,
and
E.L.Reinherz
(2011).
Antibody mechanics on a membrane-bound HIV segment essential for GP41-targeted viral neutralization.
|
| |
Nat Struct Mol Biol,
18,
1235-1243.
|
|
|
|
|
|
|
D.R.Burton
(2010).
Scaffolding to build a rational vaccine design strategy.
|
| |
Proc Natl Acad Sci U S A,
107,
17859-17860.
|
|
|
|
|
|
The most recent references are shown first.
Citation data come partly from CiteXplore and partly
from an automated harvesting procedure. Note that this is likely to be
only a partial list as not all journals are covered by
either method. However, we are continually building up the citation data
so more and more references will be included with time.
Where a reference describes a PDB structure, the PDB
code is
shown on the right.
|
|
|
Links
