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PDBsum entry 3lau
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References listed in PDB file
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Key reference
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Title
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Rational design of potent gsk3beta inhibitors with selectivity for cdk1 and cdk2.
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Authors
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D.Lesuisse,
G.Dutruc-Rosset,
G.Tiraboschi,
M.K.Dreyer,
S.Maignan,
A.Chevalier,
F.Halley,
P.Bertrand,
M.C.Burgevin,
D.Quarteronet,
T.Rooney.
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Ref.
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Bioorg Med Chem Lett, 2010,
20,
1985-1989.
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PubMed id
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Abstract
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From an HTS hit, a series of potent and selective inhibitors of GSK3beta have
been designed based on a Cdk2-homology model and with the help of several
crystal structures of the compounds within Cdk2.
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