PDBsum entry 3lan

Transferase

PDB id: 3lan

Contents

Protein chains

553 a.a.

403 a.a.

Ligands

KBT

SO4 ×6

Waters ×104

References listed in PDB file

Key reference

• Title: N1-Alkyl pyrimidinediones as non-Nucleoside inhibitors of HIV-1 reverse transcriptase.
• Authors: M.L.Mitchell, J.C.Son, H.Guo, Y.A.Im, E.J.Cho, J.Wang, J.Hayes, M.Wang, A.Paul, E.B.Lansdon, J.M.Chen, D.Graupe, G.Rhodes, G.X.He, R.Geleziunas, L.Xu, C.U.Kim.
• Ref.: Bioorg Med Chem Lett, 2010, 20, 1589-1592.
• PubMed id: 20138513

Abstract

A series of N1-alkyl pyrimidinediones were designed, synthesized and evaluated as HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs). Our efforts identified compound 10b, which represents the lead compound in this series with pharmacokinetics and antiviral potency that may support once-daily dosing.