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PDBsum entry 3l8p
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Contents |
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* Residue conservation analysis
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PDB id:
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Transferase
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Title:
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Crystal structure of cytoplasmic kinase domain of tie2 complexed with inhibitor cep11207
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Structure:
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Angiopoietin-1 receptor. Chain: a. Fragment: tie2 fragment 808-1124. Synonym: tyrosine-protein kinase receptor tie-2, htie2, tyrosine- protein kinase receptor tek, tunica interna endothelial cell kinase, p140 tek. Engineered: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: tek, tie2. Expressed in: escherichia coli. Expression_system_taxid: 562
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Resolution:
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2.40Å
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R-factor:
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0.238
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R-free:
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0.265
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Authors:
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A.A.Fedorov,E.V.Fedorov,D.Pauletti,S.L.Meyer,R.L.Hudkins,S.C.Almo
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Key ref:
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A.A.Fedorov
et al.
Crystal structure of cytoplasmic kinase domain of tie complexed with inhibitor cep11207.
To be published,
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Date:
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03-Jan-10
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Release date:
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06-Oct-10
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PROCHECK
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Headers
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References
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Q02763
(TIE2_HUMAN) -
Angiopoietin-1 receptor from Homo sapiens
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Seq:
Struc:
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1124 a.a.
292 a.a.
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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Enzyme class:
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E.C.2.7.10.1
- receptor protein-tyrosine kinase.
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Reaction:
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L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H+
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L-tyrosyl-[protein]
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+
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ATP
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=
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O-phospho-L-tyrosyl-[protein]
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+
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ADP
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+
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H(+)
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Links
