UniProt functional annotation for Q9WV48



	UniProt functional annotation for Q9WV48

UniProt code: Q9WV48.

Organism: Rattus norvegicus (Rat).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus.

Function: Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction. Overexpression promotes maturation of dendritic spines and the enlargement of spine heads via its ability to recruit Homer to postsynaptic sites, and enhances presynaptic function. {ECO:0000269|PubMed:11498055, ECO:0000269|PubMed:18287537}.

Subunit: May homomultimerize via its SAM domain. Interacts with the C- terminus of SSTR2 via the PDZ domain. Interacts with SHARPIN, SPTAN1 and DLGAP1/GKAP. Part of a complex with DLG4/PSD-95 and DLGAP1/GKAP. Interacts with BAIAP2 (By similarity). Interacts with IGSF9. Interacts with HOMER1 and HOMER3 (PubMed:19345194). {ECO:0000250, ECO:0000269|PubMed:10433268, ECO:0000269|PubMed:10433269, ECO:0000269|PubMed:10488079, ECO:0000269|PubMed:11178875, ECO:0000269|PubMed:11509555, ECO:0000269|PubMed:12954649, ECO:0000269|PubMed:15340156, ECO:0000269|PubMed:19345194}.

Subcellular location: Cytoplasm {ECO:0000269|PubMed:10433269}. Cell junction, synapse {ECO:0000269|PubMed:10433269}. Cell junction, synapse, postsynaptic density {ECO:0000269|PubMed:10433269}. Note=Colocalizes with alpha-latrotoxin receptor 1.

Tissue specificity: Expressed only in brain (neuropil of cortex, CA1 region hippocampus and molecular layer of cerebellum).

Developmental stage: Expression increases from low levels at birth to high levels at 3-4 weeks before dropping slightly in adulthood. Expressed in the cortex and the molecular layer of the cerebellum at postnatal day 7. Isoform 2 expression does not change during development of both cortex and cerebellum. Isoform 4 expression decreases significantly during development of cortex but not cerebellum. {ECO:0000269|PubMed:10506216}.

Similarity: Belongs to the SHANK family. {ECO:0000305}.

Sequence caution: Sequence=AAD29417.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAF02498.1; Type=Erroneous initiation; Evidence={ECO:0000305};

Annotations taken from UniProtKB at the EBI.


Organism:		Rattus norvegicus (Rat).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus.



Function:		Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction. Overexpression promotes maturation of dendritic spines and the enlargement of spine heads via its ability to recruit Homer to postsynaptic sites, and enhances presynaptic function. {ECO:0000269\|PubMed:11498055, ECO:0000269\|PubMed:18287537}.


Subunit:		May homomultimerize via its SAM domain. Interacts with the C- terminus of SSTR2 via the PDZ domain. Interacts with SHARPIN, SPTAN1 and DLGAP1/GKAP. Part of a complex with DLG4/PSD-95 and DLGAP1/GKAP. Interacts with BAIAP2 (By similarity). Interacts with IGSF9. Interacts with HOMER1 and HOMER3 (PubMed:19345194). {ECO:0000250, ECO:0000269\|PubMed:10433268, ECO:0000269\|PubMed:10433269, ECO:0000269\|PubMed:10488079, ECO:0000269\|PubMed:11178875, ECO:0000269\|PubMed:11509555, ECO:0000269\|PubMed:12954649, ECO:0000269\|PubMed:15340156, ECO:0000269\|PubMed:19345194}.
Subcellular location:		Cytoplasm {ECO:0000269\|PubMed:10433269}. Cell junction, synapse {ECO:0000269\|PubMed:10433269}. Cell junction, synapse, postsynaptic density {ECO:0000269\|PubMed:10433269}. Note=Colocalizes with alpha-latrotoxin receptor 1.
Tissue specificity:		Expressed only in brain (neuropil of cortex, CA1 region hippocampus and molecular layer of cerebellum).
Developmental stage:		Expression increases from low levels at birth to high levels at 3-4 weeks before dropping slightly in adulthood. Expressed in the cortex and the molecular layer of the cerebellum at postnatal day 7. Isoform 2 expression does not change during development of both cortex and cerebellum. Isoform 4 expression decreases significantly during development of cortex but not cerebellum. {ECO:0000269\|PubMed:10506216}.
Similarity:		Belongs to the SHANK family. {ECO:0000305}.
Sequence caution:		Sequence=AAD29417.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAF02498.1; Type=Erroneous initiation; Evidence={ECO:0000305};